The School of Greatness podcast examines the critical issue of gender disparities in medical research and healthcare. For decades, women have been systematically excluded from clinical studies, leading to a lack of gender-specific treatments and understanding of female biology. The episode sheds light on how this oversight has affected areas like heart disease and menopause care.
It advocates for increased prioritization of women's health research and better training for healthcare providers. The discussion also explores emerging technologies that could potentially delay menopause and transform how women experience it. With open dialogues on sensitive topics like hormone replacement therapy, the episode aims to empower women to take control of their well-being.
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Historically, women have been systematically excluded from medical research, resulting in skewed data that has significantly impacted healthcare treatments available to women, says the podcast. One consequence of excluding women was the [restricted term] birth defect tragedy. Additionally, researchers often avoid studying women due to hormonal complexities, preferentially studying men instead. This gender bias leads to issues like cardiovascular medications being less effective for women.
The podcast asserts there is an urgent need to recognize biological differences between men and women. It advocates for mandatory menopause and gender-specific disease training for healthcare providers, as well as advocacy and legislative action to prioritize women's health research.
Menopause increases risks like cardiovascular disease and osteoporosis in women due to estrogen drop, according to the podcast. It discusses using systemic estrogen replacement therapy (HRT) to manage symptoms like hot flashes and mitigate health risks. Emotionally, menopause can trigger depression, anxiety, and mood swings.
Despite being the standard treatment, Haver states that only 4-6% of eligible women use HRT due to outdated fears. The podcast recommends lifestyle changes like diet, exercise and stress management for those avoiding HRT.
The podcast explores emerging technologies that may extend ovarian lifespan and delay menopause. Haver discusses a hormone called AMH that could prolong estrogen production without prolonging childbearing. She speculates future generations could make menopause optional through such advancements starting in perimenopause.
Rhonda Patrick introduces the concept of cellular rejuvenation through epigenetic reprogramming. She cites Shinya Yamanaka's work reprogramming cells to an embryonic state, resetting the epigenome. While challenges remain, Patrick is hopeful such advances could significantly transform how menopause and aging are experienced within decades.
1-Page Summary
Gender disparities in medical care have been a longstanding issue that requires urgent attention to ensure women receive adequate and effective treatments. Years of women's exclusion from medical studies, combined with gender bias in research, have led to a medical system that often neglects the unique needs of women.
Historically, women have been systematically excluded from medical research. This exclusion was not addressed by law until 1993 which means that, prior to that, a majority of clinical trials primarily included male participants. This neglect resulted in skewed data that has significantly impacted healthcare treatments available to women.
One catastrophic example was the use of [restricted term] in pregnant women to combat nausea which led to severe birth defects. As a consequence, regulatory bodies excluded all women from studies to avoid potential pregnancy risks. This blanket exclusion has had long-term effects on the understanding of how various medications and treatments affect women specifically.
Researchers often avoid studying women due to higher costs and complexities, as women's hormonal cycles can complicate study results. As a result, they preferentially study men and then infer that the results apply to women. This inference overlooks fundamental gender and sex differences that can alter how diseases manifest and how treatments should be applied.
Cardiovascular medications, like statins, serve as an example where clinical assumptions based on male-dominated research fall short for women. Studies indicate that statins do not demonstrate the same preventive benefits for heart attack or cardiovascular death in women as they do in men. Despite this, statins are routinely prescribed to women because of evidence gathered predominately from men.
There is a pressing need to recognize and address the biological and physiological differences between men and women in medical care.
It's critical for all clinicians interacting with ...
Gender Disparities in Medical Care: Need For Women-Centric Research
Menopause is a significant life transition for women, affecting their physical and emotional well-being, often increasing the risk of cardiovascular disease, osteoporosis, and leading to other health concerns.
The onset of menopause can trigger a range of changes that impact a woman's health. Postmenopausal women face a 50% increased risk of cardiovascular disease as they become more [restricted term] resistant and their cholesterol levels rise; estrogen previously played a protective role for heart vessels. Health care providers sometimes prescribe statins to manage the significant increase in cholesterol levels, although there is no definitive evidence that statins decrease the risk of heart attacks in women.
Menopause is characterized by the drop in estrogen levels, leading to symptoms like hot flashes. Haver discusses using systemic estrogen replacement with a patch to manage symptoms and mitigate risks such as osteoporosis and cardiovascular issues. Additionally, she uses topical estrogen on her face to combat thinning skin, a symptom caused by the loss of collagen associated with menopause.
Emotionally, menopause can be a tumultuous time, leading to more cases of depression, anxiety, and mood swings. Haver reflects on the profound emotional changes women endure during menopause, asserting that preventing these could significantly improve women’s mental health, resilience, and ability to function during this period.
Despite Hormone Replacement Therapy (HRT) being the gold standard for ...
Menopause: Physical and Emotional Effects and Management
As researchers look deeper into the human body's biological processes, the prospect of altering the menopause experience through scientific breakthroughs becomes increasingly plausible.
Mary Claire Haver discusses the potential of a hormone known as AMH that may extend ovarian lifespan. Labs and companies like OVIVA are delving into how to delay the atrophy and atresia within ovarian follicles. This innovative direction in technology and pharmacology could potentially make menopause optional, allowing women to maintain protective levels of estrogen longer without prolonging childbearing years.
Haver mentions that for future generations, such as her early 20s daughters, menopause might become optional due to hormone therapy advancements starting during perimenopause.
The discussion led by Haver and Lewis Howes centers on the speculation of completely bypassing or significantly delaying menopause. Haver suggests that beginning treatments at a younger age could stave off signals that lead to ovarian decline. This kind of intervention could redefine women's post-reproductive health.
Rhonda Patrick introduces the concept of aging as a programmed event dictated by the methyl groups on our DNA that alter over time. She references the fertility of sperm and egg cells that merge to produce youth despite the age of the individual cells, a result of the epigenome's complete reset.
Shinya Yamanaka's groundbreaking discovery allows an old cell to revert to its embryonic stem cell state by reprogramming with four transcription factors, thereby resett ...
Scientific and Technological Breakthroughs to Transform Menopause Experience
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