Podcasts > The School of Greatness > Has The Medical System Betrayed Women? How To Take Back Control of Your Health

Has The Medical System Betrayed Women? How To Take Back Control of Your Health

By Lewis Howes

The School of Greatness podcast examines the critical issue of gender disparities in medical research and healthcare. For decades, women have been systematically excluded from clinical studies, leading to a lack of gender-specific treatments and understanding of female biology. The episode sheds light on how this oversight has affected areas like heart disease and menopause care.

It advocates for increased prioritization of women's health research and better training for healthcare providers. The discussion also explores emerging technologies that could potentially delay menopause and transform how women experience it. With open dialogues on sensitive topics like hormone replacement therapy, the episode aims to empower women to take control of their well-being.

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Has The Medical System Betrayed Women? How To Take Back Control of Your Health

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Has The Medical System Betrayed Women? How To Take Back Control of Your Health

1-Page Summary

Gender Disparities in Medical Care: Need For Women-Centric Research

Historically, women have been systematically excluded from medical research, resulting in skewed data that has significantly impacted healthcare treatments available to women, says the podcast. One consequence of excluding women was the [restricted term] birth defect tragedy. Additionally, researchers often avoid studying women due to hormonal complexities, preferentially studying men instead. This gender bias leads to issues like cardiovascular medications being less effective for women.

The podcast asserts there is an urgent need to recognize biological differences between men and women. It advocates for mandatory menopause and gender-specific disease training for healthcare providers, as well as advocacy and legislative action to prioritize women's health research.

Menopause: Physical and Emotional Effects and Management

Menopause increases risks like cardiovascular disease and osteoporosis in women due to estrogen drop, according to the podcast. It discusses using systemic estrogen replacement therapy (HRT) to manage symptoms like hot flashes and mitigate health risks. Emotionally, menopause can trigger depression, anxiety, and mood swings.

Despite being the standard treatment, Haver states that only 4-6% of eligible women use HRT due to outdated fears. The podcast recommends lifestyle changes like diet, exercise and stress management for those avoiding HRT.

Scientific and Technological Breakthroughs to Transform Menopause Experience

The podcast explores emerging technologies that may extend ovarian lifespan and delay menopause. Haver discusses a hormone called AMH that could prolong estrogen production without prolonging childbearing. She speculates future generations could make menopause optional through such advancements starting in perimenopause.

Rhonda Patrick introduces the concept of cellular rejuvenation through epigenetic reprogramming. She cites Shinya Yamanaka's work reprogramming cells to an embryonic state, resetting the epigenome. While challenges remain, Patrick is hopeful such advances could significantly transform how menopause and aging are experienced within decades.

1-Page Summary

Additional Materials

Actionables

  • You can contribute to improving women's health research by participating in clinical studies if you're eligible, ensuring that data reflects a wider range of biological differences. Look for local universities or hospitals conducting research and express your interest in being a part of their studies, which can help balance the historical data skew.
  • To manage menopausal symptoms proactively, create a personalized wellness plan that includes tracking your diet, exercise, and stress levels, adjusting as needed to find what works best for your body. Use a journal or a digital health tracker to monitor your symptoms and lifestyle changes, and consult with healthcare professionals to tailor your plan effectively.
  • Educate yourself on the latest advancements in women's health, such as the potential of AMH hormone therapies or cellular rejuvenation, by following reputable medical journals and health news platforms. This knowledge can empower you to have informed discussions with your healthcare provider about new treatment options and preventative measures for conditions related to menopause and aging.

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Has The Medical System Betrayed Women? How To Take Back Control of Your Health

Gender Disparities in Medical Care: Need For Women-Centric Research

Gender disparities in medical care have been a longstanding issue that requires urgent attention to ensure women receive adequate and effective treatments. Years of women's exclusion from medical studies, combined with gender bias in research, have led to a medical system that often neglects the unique needs of women.

Medical System Neglects Women's Unique Needs

Historically, women have been systematically excluded from medical research. This exclusion was not addressed by law until 1993 which means that, prior to that, a majority of clinical trials primarily included male participants. This neglect resulted in skewed data that has significantly impacted healthcare treatments available to women.

Women's Exclusion From Studies Skewed Data, Impacting Female Treatments

One catastrophic example was the use of [restricted term] in pregnant women to combat nausea which led to severe birth defects. As a consequence, regulatory bodies excluded all women from studies to avoid potential pregnancy risks. This blanket exclusion has had long-term effects on the understanding of how various medications and treatments affect women specifically.

Gender Bias in Research Leads To Poor Women's Care

Researchers often avoid studying women due to higher costs and complexities, as women's hormonal cycles can complicate study results. As a result, they preferentially study men and then infer that the results apply to women. This inference overlooks fundamental gender and sex differences that can alter how diseases manifest and how treatments should be applied.

Cardiovascular medications, like statins, serve as an example where clinical assumptions based on male-dominated research fall short for women. Studies indicate that statins do not demonstrate the same preventive benefits for heart attack or cardiovascular death in women as they do in men. Despite this, statins are routinely prescribed to women because of evidence gathered predominately from men.

Recognize and Address Biological Differences Between Men and Women

There is a pressing need to recognize and address the biological and physiological differences between men and women in medical care.

Mandatory Menopause and Gender-Specific Disease Training For Healthcare Providers

It's critical for all clinicians interacting with ...

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Gender Disparities in Medical Care: Need For Women-Centric Research

Additional Materials

Actionables

  • You can start a peer-led book club focused on women's health issues to raise awareness and educate your community. Choose books and resources that delve into the history and current state of women's healthcare, and facilitate discussions that encourage participants to share their experiences and learn from each other. For example, your first book could be "Invisible Women: Data Bias in a World Designed for Men" by Caroline Criado Perez, which explores the gender data gap in various fields including medicine.
  • Create a personal health journal to track symptoms and treatments, emphasizing any gender-specific issues you encounter. Use this journal to document your medical history, symptoms, treatments, and how you respond to them. This can be a powerful tool when communicating with healthcare providers, ensuring that your unique needs are addressed. For instance, if you experience symptoms that are often dismissed in women, like certain types of pain, having a detailed record can help advocate for your care.
  • Engage with your healthcare ...

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Has The Medical System Betrayed Women? How To Take Back Control of Your Health

Menopause: Physical and Emotional Effects and Management

Menopause is a significant life transition for women, affecting their physical and emotional well-being, often increasing the risk of cardiovascular disease, osteoporosis, and leading to other health concerns.

Menopause Impacts Well-Being, Increasing Cardiovascular, Osteoporosis, and Other Risks

The onset of menopause can trigger a range of changes that impact a woman's health. Postmenopausal women face a 50% increased risk of cardiovascular disease as they become more [restricted term] resistant and their cholesterol levels rise; estrogen previously played a protective role for heart vessels. Health care providers sometimes prescribe statins to manage the significant increase in cholesterol levels, although there is no definitive evidence that statins decrease the risk of heart attacks in women.

Menopause Estrogen Drop Causes Symptoms Like Hot Flashes

Menopause is characterized by the drop in estrogen levels, leading to symptoms like hot flashes. Haver discusses using systemic estrogen replacement with a patch to manage symptoms and mitigate risks such as osteoporosis and cardiovascular issues. Additionally, she uses topical estrogen on her face to combat thinning skin, a symptom caused by the loss of collagen associated with menopause.

Menopause Triggers Emotional Upheaval: More Depression, Anxiety, Mood Swings

Emotionally, menopause can be a tumultuous time, leading to more cases of depression, anxiety, and mood swings. Haver reflects on the profound emotional changes women endure during menopause, asserting that preventing these could significantly improve women’s mental health, resilience, and ability to function during this period.

Hrt Is Underutilized Due to Outdated Fears Despite Being the Standard Menopausal Treatment

Hrt Aids Menopause, Heart, and Bones, yet Only 4-6% of Eligible Women Use It

Despite Hormone Replacement Therapy (HRT) being the gold standard for ...

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Menopause: Physical and Emotional Effects and Management

Additional Materials

Actionables

  • You can track your heart health by using a smartwatch or fitness tracker that monitors heart rate and blood pressure, aiming to identify any changes that might indicate an increased risk of cardiovascular disease post-menopause. By regularly checking these vitals, you can catch early signs of heart issues and seek medical advice promptly.
  • Create a "Menopause Mood Diary" where you jot down daily emotional states and any triggers for mood swings or anxiety, helping you to recognize patterns and manage emotional upheaval more effectively. This self-awareness tool can lead to better communication with healthcare providers about your mental health during menopause.
  • Engage in a "kitchen makeover" by replacing high-sodium and high-sugar items w ...

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Has The Medical System Betrayed Women? How To Take Back Control of Your Health

Scientific and Technological Breakthroughs to Transform Menopause Experience

As researchers look deeper into the human body's biological processes, the prospect of altering the menopause experience through scientific breakthroughs becomes increasingly plausible.

Researchers Seek to Extend Ovarian Lifespan and Delay Menopause

Emerging Tech Targets Biological Signals to Delay Ovarian Aging and Menopause Effects

Mary Claire Haver discusses the potential of a hormone known as AMH that may extend ovarian lifespan. Labs and companies like OVIVA are delving into how to delay the atrophy and atresia within ovarian follicles. This innovative direction in technology and pharmacology could potentially make menopause optional, allowing women to maintain protective levels of estrogen longer without prolonging childbearing years.

Haver mentions that for future generations, such as her early 20s daughters, menopause might become optional due to hormone therapy advancements starting during perimenopause.

Breakthroughs Could Enhance Women's Health Post-Reproduction

The discussion led by Haver and Lewis Howes centers on the speculation of completely bypassing or significantly delaying menopause. Haver suggests that beginning treatments at a younger age could stave off signals that lead to ovarian decline. This kind of intervention could redefine women's post-reproductive health.

Epigenetic Reprogramming and Cellular Rejuvenation: Promise For Reversing Aging

Cellular Reprogramming May Rejuvenate Aging in Animals, Hinting At Human "Tune-Up"

Rhonda Patrick introduces the concept of aging as a programmed event dictated by the methyl groups on our DNA that alter over time. She references the fertility of sperm and egg cells that merge to produce youth despite the age of the individual cells, a result of the epigenome's complete reset.

Shinya Yamanaka's groundbreaking discovery allows an old cell to revert to its embryonic stem cell state by reprogramming with four transcription factors, thereby resett ...

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Scientific and Technological Breakthroughs to Transform Menopause Experience

Additional Materials

Clarifications

  • Anti-Müllerian hormone (AMH) is a hormone produced by the ovaries that plays a crucial role in regulating the development of ovarian follicles. Higher levels of AMH are associated with a larger number of remaining eggs in the ovaries, indicating a longer reproductive lifespan. Researchers are exploring how manipulating AMH levels could potentially extend the ovarian lifespan and delay the onset of menopause. This research could lead to advancements in hormone therapy that may offer women the option to maintain hormonal balance and delay menopause effects.
  • Atrophy in ovarian follicles is the shrinking or degeneration of these structures, leading to a decrease in their size and function. Atresia, on the other hand, is the process of follicle death or degeneration, where the follicle fails to mature and is reabsorbed by the body. These processes are natural parts of the ovarian cycle and can impact fertility and hormone production in women.
  • Epigenetic reprogramming involves altering the chemical tags on DNA without changing the underlying genetic code. This process can potentially reverse or slow down aging by resetting the epigenetic marks that accumulate over time. Researchers have shown that reprogramming cells can rejuvenate them, offering a promising avenue for addressing age-related changes at a cellular level. The goal is to harness this technology to potentially improve health and extend lifespan.
  • Yamanaka factors are a set of four specific genes that can reprogram adult cells back to a pluripotent state, similar to embryonic stem cells. This reprogramming process involves introducing these factors into cells, which can reset the cells' identity and characteristics. The discovery of Yamanaka factors by Shinya Yamanaka revolutionized the field of regenerative medicine by offering a way to generate induced plurip ...

Counterarguments

  • Ethical considerations regarding the manipulation of natural biological processes, such as extending ovarian lifespan and delaying menopause, need to be thoroughly examined.
  • The long-term effects and potential risks of hormone therapies and cellular reprogramming are not yet fully understood, and caution is warranted before widespread implementation.
  • There may be unintended consequences of delaying menopause, such as increased risk of certain cancers associated with prolonged exposure to estrogen.
  • The accessibility and affordability of such treatments could exacerbate existing health disparities if only available to a privileged few.
  • The focus on delaying aging and menopause might contribute to societal pressures on women to maintain youthfulness, which could have psychological and social implications.
  • The idea of making menopause optional could undermine the acceptance of menopause as a natural stage in a woman's life, potentially stigmatizing those who choose not to undergo treatment.
  • The environmental impact of increased human lifespan due to delayed menopause and aging interventions has not been addressed, which could have significant implications for resource use and sustainability. ...

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