Discover the historic and potential future uses of UV light in infectious disease prevention in this intriguing episode of "Unexplainable," featuring insights from speakers Noam Hassenfeld, Dylan Matthews, David Brenner, and Jose-Luis Jimenez. The episode delves into the pioneering experiments of William and Mildred Wells from the 1930s, whose work with UV irradiation chambers in classrooms paved the path for contemporary research in combatting airborne pathogens. With the COVID-19 pandemic fueling a renewed interest in air disinfection, this timely discussion explores the viability and safety of far-UVC light as a modern-day mitigation strategy.
The narrative weaves through the complexities and debates surrounding the use of UV light against viruses, touching on both the promising advantages of this technology and the potential risks, such as ozone production and air quality concerns. The presence of Kim Moss brings additional depth to the conversation, while the speakers collectively emphasize the importance of further research and large-scale studies. This episode of "Unexplainable" invites listeners to consider the evolving science behind disease control and the critical examination of novel methods in our ongoing fight against airborne illnesses.
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In the 1930s, William and Mildred Wells conduct experiments using ultraviolet (UV) light to combat airborne infectious diseases in classrooms. They create irradiation chambers equipped with UV rays with the hypothesis that these could eliminate pathogens lingering in the air after being expelled by an infected person. Their work shows a reduction in the transmission of airborne diseases like measles, effectively establishing a foundation for future environment-based disease control research.
The COVID-19 pandemic brings a resurgence of interest in air disinfection, specifically the potential of ultraviolet (UV) light, with scientists investigating the use of far-UVC light for this purpose. Kim Moss and David Brenner find that far-UVC light, particularly at 222 nanometers, kills pathogens including viruses effectively and may be safe for human exposure. Dylan Matthews compares its efficacy favorably to traditional ventilation systems. However, concerns arise about the production of ozone from far-UVC light, which can be harmful and lead to indoor air pollution when it reacts with volatile organic compounds. Debates ensue on the risks and mitigation strategies for ozone production, with experts like Jose-Luis Jimenez calling for careful implementation in high-risk settings to avoid indiscriminate use due to concerns about air quality.
The ongoing debate underscores the need for further research to assess the safety and effectiveness of using low wavelength UV light for air disinfection. Large-scale studies are required to provide direct evidence and address concerns about the impact on air quality and human health. Early small-scale studies report no significant discomfort in eye health, and extended tests on mice have not shown detrimental effects, but challenges like increased air pollution deaths and ozone production need empirical data. Trials in controlled environments such as oil rigs, where health and air quality can be closely monitored, are proposed. Participants would need to be fully informed of the risks, especially possible exposure to contaminants like ozone. Matthews emphasizes the necessity for more data on possible side effects and the importance of evaluating the cost-effectiveness of UV light use in pandemic control compared to its benefits, suggesting a pressing demand for detailed insights into its economic and health impacts.
1-Page Summary
In the 1930s, William and Mildred Wells conducted pioneering experiments to combat airborne infectious diseases in school classrooms using ultraviolet (UV) light.
The Wellses theorized that infectious diseases could linger in the air long after being expelled from an infected person and sought a way to eliminate these pathogens. They engineered a method to purify the air by placing irradiation chambers equipped with UV rays in classrooms.
Their innovative approach provided evidence ...
The Experiment of William and Mildred Wells in the 1930s
Since the COVID-19 pandemic highlighted aerosol transmission of diseases, there is a renewed emphasis on air disinfection methods, including UV irradiation.
Scientists are currently experimenting with far-UVC light as a method for air disinfection.
Kim Moss states that far-UVC light, specifically at a wavelength of 222 nanometers, is highly effective at eliminating a range of pathogens including viruses, bacteria, mold, and allergens. Medical physicist David Brenner has been at the forefront of this research, indicating that this type of UV light may be safe for human exposure while effectively killing microorganisms. Research has shown that low doses of far-UVC light can kill 99.9% of the coronavirus and is approximately 95% effective against swine flu.
Dylan Matthews notes that far-UVC light could potentially reduce the spread of respiratory illnesses better than traditional ventilation systems due to its ability to purify the air at a rate comparable to numerous air changes per hour.
However, the use of far-UVC light is not without its potential drawbacks. One concern is that its interaction with oxygen may produce ozone, which can be detrimental when inhaled. Ozone can also react with volatile organic compounds (VOCs) such as those emitted during cooking or from personal care products, potentially leading to indoor ...
Renewed Interest in Air Disinfection
The discussion highlights the necessity for comprehensive research to establish both the safety and effectiveness of using low wavelength UV light for air disinfection.
There is an urgency for direct evidence through large-scale studies that can confirm the safety and effectiveness of low wavelength UV light deployment, especially regarding its impact on air quality and human health. So far, ongoing smaller-scale studies, such as one in a classroom setting using a shorter wavelength UV light, have not reported any noticeable difference in eye comfort. Similarly, long-term experiments on mice exposed to lower wavelength UV light have shown no effects on skin or eyes, yet questions about the air remain.
One concern raised by Jimenez involves the possibility of increased air pollution deaths due to low wavelength UV usage, a hypothesis that awaits empirical data from a large-scale application. A proposed method for acquiring such data is piloting the technology on an oil rig, an environment ideal for controlled testing due to isolation, staggered shifts, and the capability for regular health and air quality monitoring. Any such pilot program would require informed consent from participants, who must be aware ...
Need for Further Research
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