In this episode of The Peter Attia Drive, Dr. Trenna Sutcliffe provides insights into the diagnosis and treatment of Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD), and anxiety in children. She explains the challenges of identifying these conditions, which lack biomarkers and rely on assessing behavioral traits across multiple environments.
Sutcliffe and Attia explore the role of genetics and environmental factors, advocate for personalized treatment plans combining behavioral interventions and pharmacotherapy, and highlight the shortage of trained professionals, especially in non-urban areas. They also discuss the need for bridging healthcare and education systems to provide comprehensive care for children with these conditions.
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Drs. Trenna Sutcliffe and Peter Attia discuss the complexity of diagnosing Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD), and anxiety in children. These "three A's" lack biomarkers, relying on checklists of traits assessed across environments. ASD can be diagnosed around 18 months, ADHD closer to school age, though anxiety may be normal unless severely impairing function. Sutcliffe notes around 50% of individuals with ASD also have ADHD, and 40% have anxiety.
ASD has high heritability around 90%, but involves hundreds of genes, each child having a unique "fingerprint." Still, environmental factors like maternal stress, pollution, diet, and toxins play a role. Sutcliffe and Attia discuss epigenetics possibly passing environmental effects across generations.
Sutcliffe advocates for personalized treatment plans combining behavioral interventions like applied behavior analysis (ABA) and pharmacotherapy. While ABA can be controversial if done poorly, when conducted respectfully by trained therapists it can be beneficial, though therapist availability is limited. Medications like stimulants and SSRIs can improve focus when combined with behavioral parent training, but require close monitoring.
Finding integrated, multidisciplinary care teams is difficult outside major cities, with families often piecing together disparate providers. Attia and Sutcliffe raise concerns about the shortage of trained professionals to meet growing needs, especially in non-urban areas where multidisciplinary cooperation is scarce.
Sutcliffe emphasizes bridging healthcare and education through collaboration between medical and school staff, attending IEP meetings, and classroom inclusion. However, current funding structures hinder integrated comprehensive care, with debate over whether conditions should be addressed primarily through healthcare or education systems.
1-Page Summary
In a comprehensive discussion of behavioral clinical diagnoses, Dr. Trenna Sutcliffe and Peter Attia delve into the complexities surrounding the assessment and comorbidities of Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD), and anxiety in children.
Sutcliffe and Attia discuss how diagnoses of ASD, ADHD, and anxiety—referred to as the three A's—are made based on a set of clinical traits and characteristics, with no definitive biomarkers, blood tests, or brain scans to diagnose these conditions. Clinicians must assess the impairment caused by these traits in multiple environments such as home, school, and other social settings to determine if the developmental or behavioral criteria for each condition are met.
Autism can be diagnosed as young as 18 months. Although signs can sometimes be evident at 15 months, clinicians typically wait a few more months due to rapid developmental changes at that age. For ADHD, while it can technically be diagnosed in children as young as four years old, interventions often start closer to school age due to a wide range of behaviors that young children may exhibit. Anxiety is regarded as a normal emotion unless it's severe enough to cause impairment in functioning, such as separation anxiety or selective mutism in preschoolers.
Sutcliffe underscores the challenge of diagnosing these conditions due to significant symptom overlap, particularly noting that around 50% of individuals with ASD also have ADHD, and 40% have anxiety. The diagnostic process can involve multiple visits, direct assessments with the child, and taking the history with the parents, alongside information from other sources like teachers and therapists to get different perspectives on the child's behavior.
Comorbidities are common among these developmental disorders. Sutcliffe addresses the tendency to give diagnoses based on testing and checklists without always understanding the deeper issues behind a child's behavior. When ADHD medication causes side effects affecting mood, children might seem "less social and funny," which can be mistaken for decreased impulsiveness and spontaneity.
There's significant overlap between ADHD and anxiety, with many children with ADHD also experiencing anxiety, mood challenges, learning disabilities, or oppositional behaviors.
Sutcliffe also touches on oppositional defiant disorder (ODD), characterized by arguing a ...
Diagnostic criteria and comorbidities of ASD, ADHD, and anxiety
Sutcliffe and Peter Attia delve into the complexities of Autism Spectrum Disorder (ASD) and how both genetic and environmental factors contribute to the condition.
Sutcliffe communicates to parents that the traits identified within diagnoses like ASD have a substantial genetic component. The heritability of ASD ranges from 70% to 98%, with Sutcliffe noting it's well over 90%. Attia also emphasises the strong genetic component, indicating it's about 85 to 90% heritable. They contend that ASD is not linked to a single gene; rather, hundreds or even a thousand genes may be associated with the condition, with each individual presenting multiple genetic changes. Sutcliffe agrees that each child with autism has a unique genetic "fingerprint," which reinforces the involvement of numerous genes that could vary from one individual to another.
Siblings of children with autism not only face a risk for autism but also for autism-like traits and the broader autism phenotype, as well as other developmental disabilities, such as language delays and ADHD. This indicates the genetic heritability of these conditions.
Sutcliffe and Attia also recognize the role of environmental factors in ASD. Pollution, maternal infection, prolonged fevers during pregnancy, the health of the placenta, parental stress, and parental age have all been implicated in autism. Sutcliffe specifically mentions maternal stress, pollution, maternal diet, and parental age as environmental contributors to autism. Attia discusses the dramatic increase in type 2 diabetes, suggesting that while genetics play a role, the primary causation seems to be environmental, notably the change in diet. Extending this logic to autism, Attia questions whether environmental factors could be driving an increase in the condition.
The substantial rise in ASD prevalence has led to research into environmental factors and epigenetics. Sutcliffe points out that the environment impacts methylation and epigenetics. She notes that while autism has a genetic component, it's also associated with various environmental "hits," meaning that a combina ...
Genetics and environmental factors contributing to these conditions
The multidisciplinary clinic led by Trenna Sutcliffe underscores the necessity for a multifaceted treatment plan that includes behavioral interventions and pharmacotherapy to manage symptoms effectively.
Sutcliffe elaborates on personalized care and the importance of understanding each child's specific issues and behaviors to craft an effective treatment plan. She emphasizes the necessity of proactive provider engagement in creating a collaborative treatment team involving speech therapists, teachers, and regular meetings. Sutcliffe values the skills in parent training, differentiating it from basic education, and highlights various therapies such as applied behavior analysis (ABA) for autism and behavioral interventions for ADHD. She discusses the role of ABA in breaking down foundational skills into components, from which larger skills are aggregated. Sutcliffe also mentions discrete trial teaching and more naturalistic ABA methods, such as pivotal response treatment (PRT), which involve training parents in ABA techniques to use in everyday settings. The ability for a "quarterback" to guide treatment decisions, such as whether ABA might be beneficial, is noted as important for personalized care. Sutcliffe touches on ABA's controversial aspects, acknowledging the controversy surrounding discrete trial due to its perception as repetitive and non-relationship based. However, when conducted respectfully and integrated into daily life, ABA can be an effective part of treatment and is covered by insurance in California when the child has an autism diagnosis. Although, the demand for qualified therapists often exceeds their availability.
Sutcliffe underlines that ABA should be conducted by well-trained individuals who recognize its nuances. When ABA is implemented poorly or without understanding autism and behavioral therapy, it may not be helpful or significant. The goal of ABA is to integrate and generalize skills in the child’s life, such as in classrooms and other real-life situations.
Sutcliffe indicates that the use of medication depends on the child’s age and severity of ADHD, favoring behavioral interventions especially in younger children. For children six years and older, medication is recommended along with behavioral parent training. Sutcliffe notes the benefits of pharmacotherapy, explaining that medications like stimulants ([restricted term] and amphetamines), non-stimulants, and SSRIs can significantly improve focus and make children feel more successful at school. She points out that medications like [restricted term] and [restricted term] work by increasing [restricted term] and [restricted term] levels, and discusses the potential for mixing stimulants and non-stimulants to manage symptoms. She also acknowledges the potency of ADHD medications and the ...
Multidisciplinary approach to treatment, including the use of behavioral therapies and pharmacotherapy
As discussed by Peter Attia and Trenna Sutcliffe, families living outside of major cities face significant hurdles in accessing integrated, personalized care especially for children with developmental conditions like autism, ADHD, and anxiety.
Sutcliffe and Attia recognize that the journey of addressing developmental conditions is a long-term commitment requiring integration into a child's life. However, this can be particularly challenging in non-urban areas where multidisciplinary resources are scarce. Families are often left to piece together care from various providers, and they struggle to coordinate the different interventions necessary for their children’s care.
Peter Attia raises concerns about the shortage of multidisciplinary teams needed to effectively treat the growing number of children affected by these conditions. In his discussion with Sutcliffe, they touch on the scarcity of professionals who can meet the psychological needs of these children. Sutcliffe emphasizes the importance of multidisciplinary cooperation to understand and treat the whole child, which typically involves therapists, psychologists, teachers, among others.
Attia and Sutcliffe question whether the autism treatment industry has kept pace with the increasing prevalence of the condition, raising concerns about the burden ...
Challenges in accessing care, particularly in non-urban areas
Trenna Sutcliffe and Peter Attia engage in a discussion that underscores the crucial need for collaboration and integration between educational systems and healthcare, especially in relation to children with developmental conditions such as autism, ADHD, and anxiety.
Educational settings are crucial for supporting a child’s development and learning; hence, integrating healthcare into this environment is vital for the well-being of children with certain developmental conditions.
Sutcliffe emphasizes bridging educational, mental health, and medical systems as a way to make an impactful difference on child health. The discussion includes her belief in the importance of community collaboration, which involves educational aspects such as school observations, attending Individualized Education Program (IEP) meetings, and working directly with teachers in the classroom. The role of IEPs in schools illustrates how care is being integrated into the educational system to support children with conditions like Autism Spectrum Disorder (ASD).
The conversation reflects some concerns with the existing structures of funding and reimbursement, as these hinder the ability to deliver comprehensive and integrated care.
The role of education and integration between healthcare and education systems
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