In this episode of The Jordan B. Peterson Podcast, Dr. Benjamin Bikman explains the biological mechanisms behind insulin resistance, a widespread metabolic condition linked to chronic diseases like diabetes, cancer, and Alzheimer's. He explores how high-carb diets contribute to chronically elevated insulin levels and resistance, driving conditions from obesity to heart disease.
Bikman examines the history of dietary guidelines in the US, suggesting flawed recommendations driven by special interests led to an overconsumption of processed carbs and the subsequent rise in health issues. He discusses the potential benefits of low-carb and ketogenic diets as alternative fuel sources to combat insulin resistance-related conditions such as type 2 diabetes, neurological disorders, and cognitive decline.
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Bikman explains [restricted term] is essential for regulating sugar and fat, but excessive carb consumption leads to chronically high [restricted term], driving [restricted term] resistance. Peterson notes [restricted term] resistance causes metabolic issues and increases disease risk.
Bikman clarifies organisms develop resistance to excessive exposure like [restricted term] resistance to avoid harm. This results in metabolic issues and implies higher disease risk like obesity, cancer, and Alzheimer's. Medications for diabetes may worsen resistance over time.
High [restricted term] signals fat cells to grow. Large fat cells resist [restricted term] to avoid bursting, leaking fatty acids and causing fatty liver disease and ectopic fat deposition in tissues not meant for fat storage.
Peterson lists conditions like type 2 diabetes, cancer, heart disease, erectile dysfunction, infertility as linked to excessive carbs. Bikman ties these to [restricted term] resistance as symptoms of the same issue - 88% of US adults have at least one element of metabolic syndrome, indicating [restricted term] resistance prevalence. Type 2 diabetes stems from [restricted term] resistance. Clinicians focus on glucose over the more important marker [restricted term]. Erectile dysfunction relates to [restricted term] resistance impairing blood vessels' ability to produce nitric oxide for vasodilation. Alzheimer's involves the brain becoming [restricted term] resistant due to high-carb diets, contributing to obesity and further [restricted term] resistance.
Bikman and Peterson discuss how the body efficiently stores carbs as fat, problematic with calorie-dense foods. High [restricted term] drives down sugar but increases [restricted term] resistance. Carbs raise [restricted term], shifting to sugar burning over fat burning.
Historically, type 1 diabetics thrived on a low-carb, carnivore diet without needing [restricted term]. The shift to a carb-dense diet is tied to obesity, type 2 diabetes, and chronic disease. Peterson blames abundant, cheap, promoted processed foods high in carbs and sugars. Bikman cites "sugar bombs" like juices without fiber and ubiquitous high fructose corn syrup as direct contributors to [restricted term] resistance.
Peterson and Bikman argue the original food pyramid promoted a flawed high-carb diet, fueling obesity and diabetes. Its architects had biases like certain religious beliefs minimizing meat intake. Policies historically encouraged calorie-dense but unhealthy carbs over nutritious foods to prevent starvation. Peterson implies the architects foreknew their guidelines would drive a health crisis.
The food pyramid critique suggests current policies don't support diets like low-carb, high-fat, high-protein - the type that could be more optimal for health.
Bikman says ketosis boosts fat metabolism, linking to benefits for [restricted term] resistance. For type 2 diabetes, lowering [restricted term] through reduced carbs can reverse the disease. Peterson supports low-carb diets for Alzheimer's and diabetes. Historical human diets likely included periods of low carbs/autophagy, emulated by a carnivore diet.
Bikman notes fat doesn't require [restricted term], is a better fuel for diabetics with fewer blood glucose swings, and the brain prefers ketones over glucose when available.
Bikman discusses ketogenic diets' therapeutic potential for conditions with inefficient brain glucose utilization like Alzheimer's, epilepsy, migraines, depression - the brain can use ketones instead when available, even with [restricted term] resistance.
Case reports show dementia/Alzheimer's patients improving cognitively on a ketogenic diet, some regaining ability to perform daily tasks after entering ketosis. Bikman is concerned current type 2 diabetes treatments increasing [restricted term] are counterproductive, suggesting lifestyle changes could reduce medication reliance.
1-Page Summary
[restricted term] plays a critical role in regulating the metabolism of sugar and fat in the body. However, chronically high levels of [restricted term] can lead to [restricted term] resistance, which is associated with a wide array of metabolic issues and an increased risk of various diseases.
Bikman explains that [restricted term] is essential for the body to regulate sugar and fat levels; without it, a person would not survive. Unfortunately, excessive carbohydrate consumption can lead to chronically high [restricted term] levels, which may become the main driver of [restricted term] resistance. Peterson raises the issue of how [restricted term] resistance can lead to a cascade of health problems. [restricted term], while famously known for lowering high blood sugar, can have catastrophic systemic effects when the body becomes resistant to its action.
Bikman clarifies that organisms develop resistance to stimuli like [restricted term] to avoid associated excessive exposure harm. This resistance results in metabolic issues and implies a higher risk of diseases, including obesity. He also notes that medications for diabetes, which increase [restricted term] production, could worsen [restricted term] resistance over time, making patients more susceptible to other health issues such as cancer and Alzheimer's disease. These medications could be exacerbating the issue by making the pancreas work overtime rather than addressing the underlying condition.
The hosts explain that part of [restricted term] resistance involves the growth of fat cells due to continuous high [restricted term] levels signaling these cells to enlarge. Fat cell size, more than the total amount of body fat, can significantly affect cardiometabolic health. Large fat cells may resist [restricted term]'s effects to avoid bursting and could start leaking fatty acids as a form of self-protection. This leakage can lead to fatty liver disease and ectopic fat deposition as fat accumulates in tissues not meant for fat storage.
Expanding fat cells that have become [restricted term] resistant contribute to ectopic fat deposition, particularly in the liver and pancreas, which are not designed to store fat. This process can trigger various conditions such as fatty liver disease.
Peterson delves into the catastrophic health effects linked to [restricted term] resistance. He lists conditions such as type 2 diabetes, cancer, heart disease, erectile dysfunction, reproductive dysfunction, and more as conditions connected to excessive carbohydrate intake. Bikman ties these chronic diseases to [restricted term] resistance, viewing them as symptoms of the same underlying issue.
Metabolic syndrome, which includes [restricted term] resistance, is now known to contribute significantly to these chronic ...
The Biology and Effects of Insulin Resistance
Jordan Peterson and Dr. Benjamin Bikman explore the role of carbohydrate consumption in the development of [restricted term] resistance, emphasizing the health consequences of a high-carb diet.
Bikman and Peterson discuss the metabolic pathway where carbohydrates are rapidly converted metabolically into sugar and then stored as fat, a process that exacerbates with the consumption of calorie-dense foods. Peterson points to the detrimental cycle wherein [restricted term] drives sugar down but simultaneously increases [restricted term] resistance. Carbohydrates are described as high-energy sources that can promote fat cell growth when combined with high [restricted term] levels. As carbs increase [restricted term] levels, the body transitions into sugar burning mode rather than fat burning mode.
Peterson and Bikman delve into the problems stemming from continuous overconsumption of carbohydrates and sugars, considering the historical shifts in dietary practices.
They examine the historical treatment of type 1 diabetics with an almost entirely carnivore diet, emphasizing that the body did not need [restricted term] to metabolize this diet, as opposed to current high-carbohydrate diets. This transition to a carb-dense diet for type 1 diabetics is tied to [restricted term] resistance, obesity, type 2 diabetes, and other chronic diseases. Peterson suggests that a fundamental problem with America's health is the abundance of carbohydrates, often seen in the form of cheap, heavily promoted processed foods that are omnipresent in the average diet.
Bikman points to the consumption of "sugar ...
Carbohydrates and Sugar in Insulin Resistance
In a pointed discussion on the US dietary guidelines, experts argue that the nation's approach to nutrition has been deeply flawed and influenced by special interests and misinformation.
Jordan Peterson and Benjamin Bikman analyze the origins and impact of the US food pyramid, suggesting that biased architects with insufficient scientific backing shaped these guidelines.
The creators of the original food pyramid promoted a high-carbohydrate diet. Peterson and Bikman point to the dramatic rise in obesity and diabetes rates as evidence of its flawed nature. They imply that these conditions are exacerbated by dietary recommendations that prioritize high carbohydrate intake over other nutrients. Bikman highlights criticism of the government's role in conducting what Dr. Philip Handler referred to as an uncontrolled nutritional experiment on the American public without consent.
Bikman also discusses how certain religious beliefs, particularly those of the Seventh-day Adventists who helped write the food pyramid, influenced its emphasis on minimizing meat intake and shaped the American Dietetics Association's guidelines, perpetuating these biases in dietary licensure.
There was further critique on the dietary landscape in the US, which historically encouraged the consumption of calorie-dense carbohydrates due to economic efficiencies and the need for calorie-rich foods to prevent starvation. The experts argue that while this might have been an economical solution at the time, it has not led to optimal health outcomes.
Peterson indicates that the selection of vegetables and fruits has changed considerably, although no explicit details are given in the discussion. ...
Politics and History of US Dietary Recommendations
Experts like Bikman and Jordan Peterson discuss the transformative effects of low-carb and ketogenic diets on various chronic health conditions.
Bikman suggests that being in ketosis significantly increases the fat tissue metabolic rate, linking to boosted metabolism and implying benefits for [restricted term] resistance conditions. He notes that in type 2 diabetes, characterized by too much [restricted term], lowering [restricted term] levels through reduced carbohydrate intake can reverse the disease. Peterson also supports dietary intervention, notably for diseases like Alzheimer's and diabetes, indicating that reducing high carbohydrate intake can profoundly improve life both in the short and long term.
Peterson discusses historical human diets, suggesting that low carbohydrate intake leading to autophagy, where the body digests damaged tissues, may be emulated by a carnivore diet. Reducing carbohydrate intake, Peterson argues, may also address [restricted term] resistance-related conditions such as erectile dysfunction and potentially extend life. Bikman and Peterson encourage consideration of a low-carb approach as a first step for those with unhealthy lifestyles.
Bikman contends that fat does not require [restricted term] for metabolism and is a better fuel, especially for type 1 diabetics, who can experience fewer blood glucose fluctuations and require less [restricted term] with controlled carbohydrate intake. Likewise, Bikman highlights the cognitive benefits of ketones for the brain, suggesting that they are favored by the brain over glucose when available. He also mentions that ketogenic diets might act as adjuvant therapy for cancer, given that cancer cells prefer glucose and do not utilize ketones, implying that a low glucose diet hinders cancer cell growth.
Bikman's research from Boston University indicates that ketogenic diets can shrink inoperable brain tumors and reduce the need for chemotherapy dosage. Furthermore, case reports suggest rapid and significant cognitive improvements in patients with dementia or early-stage Alzheimer's through nutritional ketosis.
Bikman's conversations allude to the therapeutic potential of ketogenic diets for neurological disorders marked by inefficient glucose use by the brain, such as Alzheimer's, epilepsy, migraines, and depression. The brain has a high metabolic rate and can alternatively use glucose or ketones as fuel. He discusses the preference of ketones by the brain when available and points out that keton ...
Benefits of Low-carb/Ketogenic Diets for Chronic Health Issues
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