In this episode of The Joe Rogan Experience, Rick Doblin and Joe Rogan explore the history of psychedelics, from their early therapeutic applications to their criminalization. The discussion covers how substances like MDMA were once used in therapy, the political motivations behind their prohibition, and the historical suppression of traditional psychedelic practices across different cultures.
The conversation examines current research on psychedelic therapy, particularly MDMA's potential in treating PTSD, and the regulatory challenges these studies face. Doblin and Rogan also discuss theories about psychedelics' role in human evolution and their potential applications in addressing modern social issues, including how psychedelic experiences might influence conflict resolution and environmental awareness through promoting feelings of interconnectedness.
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In this episode, Joe Rogan and Rick Doblin explore the complex history of psychedelics, from their therapeutic use to criminalization. Doblin explains that MDMA, developed by Merck in 1912, was successfully used in therapy until 1985, when the DEA made it illegal. The 1970 act criminalizing psychedelics was, according to Nixon's domestic policy advisor John Ehrlichman, politically motivated to target civil rights movements.
Traditional psychedelic use has faced persistent suppression throughout history. Doblin describes how the Catholic Church eliminated ancient ceremonies like the Eleusinian Mysteries, while conquistadors targeted indigenous practices involving mushrooms and peyote. Even modern religious use, such as the Native American Church's peyote ceremonies and the Uñao de Vegetal's ayahuasca practices, has faced significant legal challenges.
Recent clinical trials have shown promising results for psychedelic therapy. Doblin reports that MDMA-assisted therapy for severe PTSD has been particularly successful, with two-thirds of participants no longer meeting PTSD criteria after treatment. The therapy combines traditional counseling with MDMA sessions, taking advantage of the extended period of neuroplasticity that psychedelics can induce.
However, regulatory barriers and stigma continue to slow progress. The FDA has raised concerns about study methods, particularly regarding "functional unblinding" in psychedelic research. Despite these challenges, efforts continue to expand access to psychedelic therapy, especially for veterans, first responders, and terminally ill patients.
Rogan and Doblin discuss Terence McKenna's "Stoned Ape" theory, which suggests that early human consumption of psilocybin mushrooms contributed to cognitive evolution and language development. The conversation extends to psychedelics' potential role in addressing modern challenges. Doblin shares research by Lior Roseman showing how ayahuasca sessions helped Israelis and Palestinians recognize their shared humanity.
Doblin and Rogan suggest that psychedelic experiences might offer solutions to global challenges like nuclear war and climate change by promoting interconnectedness and reducing tribalism. Through organizations like MAPS, efforts are being made to integrate these insights into medical practice and policy reform.
1-Page Summary
The hosts, Joe Rogan and Rick Doblin, examine the intricate history of psychedelics, their use in therapy, and the legal battles that followed their criminalization.
Rick Doblin recalls that MDMA, which he first tried in 1982, had been in quiet therapeutic use from around 1976 until it gained popularity as a party drug, ecstasy, and was made illegal in 1985. MDMA itself was developed by Merck in 1912 and used in therapy before Doblin knew about it. However, in 1985, the DEA made MDMA illegal on an emergency basis, effectively ending its legal use in therapy.
Reflecting on the effects of MDMA's criminalization, Doblin mourns the missed opportunities for healing that could have occurred if not for the laws prohibiting psychedelic use.
Doblin and Rogan discuss the 1970 act that criminalized psychedelics, suggesting it was part of a politically-motivated campaign targeting civil rights movements. They cite Nixon domestic policy advisor John Ehrlichman's admission that drug risks were exaggerated to justify cracking down on civil rights activists.
Additionally, Doblin speaks on the lawsuit against the DEA’s scheduling of MDMA, noting that an Administrative Law Judge’s advisory ruling for MDMA to be Schedule 3 was ignored by the DEA. Further, the DEA's initial emergency scheduling in 1985 was deemed illegal, but it wasn’t until Doblin’s organization, MAPS, sought FDA approval that there was a renewed push to reschedule the drug.
Psychedelics have a storied use in various cultures, which has often been met with suppression.
Doblin cites how ancient ceremonies such as the Eleusinian Mysteries, which used a psychedelic potion called kykeon, were exterminated by the Catholic Church. Furthermore, when conquistadors arrived in indigenous lands, they targeted shamanistic practices involving psychedelics like mus ...
The History and Regulation of Psychedelics
Rick Doblin, Joe Rogan, and Sharif Elnahal discuss the therapeutic potential of psychedelics, obstacles for their acceptance in medical practice, and the ongoing research and legalization efforts.
Recent studies and personal accounts underscore the therapeutic potential of psychedelics for mental health issues, including PTSD, depression, and addiction.
MDMA-assisted therapy trials for severe PTSD showed promising results, with two-thirds of participants no longer meeting PTSD criteria after treatments that involved therapy sessions combined with three spaced-out MDMA sessions. These results were significantly better than those in the control group, who received the same amount of therapy without MDMA.
Rick Doblin highlights the extended period of neuroplasticity induced by psychedelics, which can allow for rewiring of the brain, potentially leading to long-term changes in behavior and brain circuitry when combined with therapy. The therapy sessions often include music and headphones and typically stick to an eight-hour length, facilitating the therapeutic process.
A study involving group therapy at the Portland, Oregon VA showed that veterans supported each other during post-therapy integration. Projects using psychedelics like psilocybin and MDMA are underway to treat small numbers of veterans, first responders, and terminally ill patients. Doblin details the various approaches being explored, including cognitive behavioral conjoint therapy and MDMA-assisted therapy, which includes the partner of the PTSD sufferer and has shown improvements in both PTSD symptoms and relationship strength.
Although research shows the benefits of psychedelics, stigma, and regulatory challenges slow down the process of approval for therapeutic use.
The FDA raised concerns about "functional unblinding" during psychedelic research, as participants might discern whether they've received MDMA. This could influence study results, leading to disagreements ov ...
The Therapeutic Applications and Research on Psychedelics
Psychedelics hold a significant place in discussions about consciousness and evolution, with their potential impact on cognitive development and social structures being widely debated and researched.
Joe Rogan and Rick Doblin delve into Terence McKenna's "Stoned Ape" theory, proposing that early primate consumption of psilocybin mushrooms led to elevated consciousness, contributing to the development of language and brain growth. The theory explains the doubling of the human brain size, positing that as rainforests transformed into grasslands, the resulting increase in mushrooms consumed by primates improved visual acuity, promoted amorous behavior, and increased creativity. This chain reaction could have led to advanced hunting skills, better nutrition, and ultimately, robust brain evolution.
Psychedelics are said to deepen the sense of interconnectedness among individuals, influencing society and spirituality. Rick Doblin speaks on the essence of the spiritual aspects of psychedelics, emphasizing the potential role they could play in elevating human consciousness. He recounts his dream where a dying man stressed that studying psychedelics is crucial for feeling interconnectedness, making it less likely for people to dehumanize each other.
Rogan and Doblin discuss how psychedelics could foster a cultural shift away from conflict by promoting a sense of shared humanity. In his conversation with Doblin, Rogan discusses the contributions of groups like Combatants for Peace, consisting of former Israeli soldiers and Palestinians who now advocate for nonviolence. Research by Lior Roseman demonstrated how ayahuasca sessions impacted Israelis and Palestinians, allowing them to appreciate their commonality and recognize each other's pain. Doblin speaks to the reduction of tribalism through an understanding of interconnectedness, offering perspectives on DNA similarities among all life and how this recognition can lead to ...
Psychedelics in Consciousness and Evolution
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