Podcasts > The Joe Rogan Experience > #2319 - Rick Doblin

#2319 - Rick Doblin

By Joe Rogan

In this episode of The Joe Rogan Experience, Rick Doblin and Joe Rogan explore the history of psychedelics, from their early therapeutic applications to their criminalization. The discussion covers how substances like MDMA were once used in therapy, the political motivations behind their prohibition, and the historical suppression of traditional psychedelic practices across different cultures.

The conversation examines current research on psychedelic therapy, particularly MDMA's potential in treating PTSD, and the regulatory challenges these studies face. Doblin and Rogan also discuss theories about psychedelics' role in human evolution and their potential applications in addressing modern social issues, including how psychedelic experiences might influence conflict resolution and environmental awareness through promoting feelings of interconnectedness.

#2319 - Rick Doblin

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#2319 - Rick Doblin

1-Page Summary

The History and Regulation of Psychedelics

In this episode, Joe Rogan and Rick Doblin explore the complex history of psychedelics, from their therapeutic use to criminalization. Doblin explains that MDMA, developed by Merck in 1912, was successfully used in therapy until 1985, when the DEA made it illegal. The 1970 act criminalizing psychedelics was, according to Nixon's domestic policy advisor John Ehrlichman, politically motivated to target civil rights movements.

Traditional psychedelic use has faced persistent suppression throughout history. Doblin describes how the Catholic Church eliminated ancient ceremonies like the Eleusinian Mysteries, while conquistadors targeted indigenous practices involving mushrooms and peyote. Even modern religious use, such as the Native American Church's peyote ceremonies and the Uñao de Vegetal's ayahuasca practices, has faced significant legal challenges.

The Therapeutic Applications and Research on Psychedelics

Recent clinical trials have shown promising results for psychedelic therapy. Doblin reports that MDMA-assisted therapy for severe PTSD has been particularly successful, with two-thirds of participants no longer meeting PTSD criteria after treatment. The therapy combines traditional counseling with MDMA sessions, taking advantage of the extended period of neuroplasticity that psychedelics can induce.

However, regulatory barriers and stigma continue to slow progress. The FDA has raised concerns about study methods, particularly regarding "functional unblinding" in psychedelic research. Despite these challenges, efforts continue to expand access to psychedelic therapy, especially for veterans, first responders, and terminally ill patients.

Psychedelics in Consciousness and Evolution

Rogan and Doblin discuss Terence McKenna's "Stoned Ape" theory, which suggests that early human consumption of psilocybin mushrooms contributed to cognitive evolution and language development. The conversation extends to psychedelics' potential role in addressing modern challenges. Doblin shares research by Lior Roseman showing how ayahuasca sessions helped Israelis and Palestinians recognize their shared humanity.

Doblin and Rogan suggest that psychedelic experiences might offer solutions to global challenges like nuclear war and climate change by promoting interconnectedness and reducing tribalism. Through organizations like MAPS, efforts are being made to integrate these insights into medical practice and policy reform.

1-Page Summary

Additional Materials

Counterarguments

  • The therapeutic efficacy of MDMA for PTSD, while promising, is still under investigation, and long-term effects are not fully understood.
  • The political motivations behind the criminalization of psychedelics may have been complex and not solely aimed at targeting civil rights movements.
  • The suppression of ancient psychedelic ceremonies by the Catholic Church and conquistadors can also be viewed within the broader context of cultural and religious conflicts, rather than solely as suppression of psychedelic use.
  • Legal challenges to modern religious psychedelic use may stem from broader drug policy concerns and not necessarily from a direct opposition to religious practices.
  • Concerns about "functional unblinding" in psychedelic research highlight the need for rigorous study designs to ensure the validity and reliability of research findings.
  • The "Stoned Ape" theory is speculative and not widely accepted in the scientific community; alternative theories of cognitive evolution exist that do not involve psychedelic substances.
  • The idea that psychedelics can contribute to solving global challenges is an optimistic view that may overlook the complexity of these issues and the potential for negative outcomes from psychedelic use.
  • Efforts to integrate psychedelic therapy into medical practice must balance the potential benefits with the risks and ethical considerations of using these powerful substances.
  • The use of psychedelics in addressing conflicts, such as between Israelis and Palestinians, may not be generalizable or applicable in all contexts of geopolitical tension.
  • The push for policy reform based on the insights from psychedelic experiences must take into account the diverse perspectives and potential unintended consequences of such changes.

Actionables

  • You can deepen your understanding of the historical context by reading books on the political history of psychedelics to gain insight into how these substances have been perceived and regulated over time. For example, pick up a book like "Acid Dreams: The Complete Social History of LSD" by Martin A. Lee and Bruce Shlain to explore the nexus of psychedelics and political movements, which can provide a broader perspective on the assertions related to the criminalization of psychedelics and their impact on civil rights.
  • Engage in conversations about mental health treatments by discussing the potential of psychedelic therapy with friends or family who may be open to alternative therapies. This can be a way to disseminate information about the therapeutic benefits of psychedelics, especially for conditions like PTSD, and to potentially reduce stigma. You might share articles from reputable sources that report on the latest research findings or personal stories of those who have benefited from such treatments.
  • Explore the concept of interconnectedness by starting a personal journal where you reflect on your relationship with nature and others. Inspired by the idea that psychedelic experiences can promote a sense of unity, you can write about moments when you felt a deep connection to the world around you or when you overcame a sense of "otherness" in relation to someone from a different background. This practice can help cultivate empathy and a sense of global citizenship, which is in line with the notion that psychedelics might offer solutions to global challenges by fostering interconnectedness.

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#2319 - Rick Doblin

The History and Regulation of Psychedelics

The hosts, Joe Rogan and Rick Doblin, examine the intricate history of psychedelics, their use in therapy, and the legal battles that followed their criminalization.

Psychedelics Used In Therapy Before 1970s but Later Banned

Rick Doblin recalls that MDMA, which he first tried in 1982, had been in quiet therapeutic use from around 1976 until it gained popularity as a party drug, ecstasy, and was made illegal in 1985. MDMA itself was developed by Merck in 1912 and used in therapy before Doblin knew about it. However, in 1985, the DEA made MDMA illegal on an emergency basis, effectively ending its legal use in therapy.

Mdma: Developed by Merck In 1912, Therapy Use in 1970s-80s, Criminalized In 1985

Reflecting on the effects of MDMA's criminalization, Doblin mourns the missed opportunities for healing that could have occurred if not for the laws prohibiting psychedelic use.

1970 Act Criminalized Psychedelics, Targeted Civil Rights Movements

Doblin and Rogan discuss the 1970 act that criminalized psychedelics, suggesting it was part of a politically-motivated campaign targeting civil rights movements. They cite Nixon domestic policy advisor John Ehrlichman's admission that drug risks were exaggerated to justify cracking down on civil rights activists.

Dea's Illegal Mdma Scheduling Persisted Until Maps Sought Fda Approval

Additionally, Doblin speaks on the lawsuit against the DEA’s scheduling of MDMA, noting that an Administrative Law Judge’s advisory ruling for MDMA to be Schedule 3 was ignored by the DEA. Further, the DEA's initial emergency scheduling in 1985 was deemed illegal, but it wasn’t until Doblin’s organization, MAPS, sought FDA approval that there was a renewed push to reschedule the drug.

Psychedelics' Traditional and Religious Use Suppressed by Authorities

Psychedelics have a storied use in various cultures, which has often been met with suppression.

Ancient Cultures' Use of Psychedelics in Rituals

Doblin cites how ancient ceremonies such as the Eleusinian Mysteries, which used a psychedelic potion called kykeon, were exterminated by the Catholic Church. Furthermore, when conquistadors arrived in indigenous lands, they targeted shamanistic practices involving psychedelics like mus ...

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The History and Regulation of Psychedelics

Additional Materials

Actionables

- You can deepen your understanding of the historical context by reading books on the intersection of politics and drug policy, such as "Chasing the Scream" by Johann Hari, to gain insight into how political agendas have shaped drug laws.

  • Reading such material provides a broader perspective on the motivations behind drug legislation, which can be crucial for informed discussions or advocacy. For example, understanding the political underpinnings of the 1970s drug laws could inform your conversations with peers or when contacting representatives to advocate for policy changes.
  • Explore the cultural significance of psychedelics by attending art exhibits or virtual galleries that feature works inspired by or derived from psychedelic experiences and indigenous cultures.
  • Engaging with this art can offer a visceral understanding of the spiritual and cultural dimensions that these substances have embodied throughout history. For instance, an exhibit might display Amazonian tapestries that depict ayahuasca visions, providing a tangible connection to the traditions and values of the cultures that use these plant medicines.
  • Support sustainable and ethical sourcing of plant medicines by purchasing products from companies that invest in the preservation of indigenous lands and cultures.
  • ...

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#2319 - Rick Doblin

The Therapeutic Applications and Research on Psychedelics

Rick Doblin, Joe Rogan, and Sharif Elnahal discuss the therapeutic potential of psychedelics, obstacles for their acceptance in medical practice, and the ongoing research and legalization efforts.

Psychedelics: Potential Treatment For Ptsd, Depression, and Addiction

Recent studies and personal accounts underscore the therapeutic potential of psychedelics for mental health issues, including PTSD, depression, and addiction.

MDMA Trials Effective for Severe PTSD: 2/3 No Longer Meet Criteria

MDMA-assisted therapy trials for severe PTSD showed promising results, with two-thirds of participants no longer meeting PTSD criteria after treatments that involved therapy sessions combined with three spaced-out MDMA sessions. These results were significantly better than those in the control group, who received the same amount of therapy without MDMA.

Psychedelics Aid Trauma Processing, Promoting Lasting Positive Changes

Rick Doblin highlights the extended period of neuroplasticity induced by psychedelics, which can allow for rewiring of the brain, potentially leading to long-term changes in behavior and brain circuitry when combined with therapy. The therapy sessions often include music and headphones and typically stick to an eight-hour length, facilitating the therapeutic process.

Researching Psychedelic Therapy For Veterans, First Responders, and the Terminally Ill

A study involving group therapy at the Portland, Oregon VA showed that veterans supported each other during post-therapy integration. Projects using psychedelics like psilocybin and MDMA are underway to treat small numbers of veterans, first responders, and terminally ill patients. Doblin details the various approaches being explored, including cognitive behavioral conjoint therapy and MDMA-assisted therapy, which includes the partner of the PTSD sufferer and has shown improvements in both PTSD symptoms and relationship strength.

Regulatory Barriers and Stigma Hinder Psychedelic Medicine Approval

Although research shows the benefits of psychedelics, stigma, and regulatory challenges slow down the process of approval for therapeutic use.

FDA Delays MDMA Therapy Approval Over Study Method Concerns

The FDA raised concerns about "functional unblinding" during psychedelic research, as participants might discern whether they've received MDMA. This could influence study results, leading to disagreements ov ...

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The Therapeutic Applications and Research on Psychedelics

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Counterarguments

  • Concerns about the long-term safety of psychedelics have not been fully addressed, as most studies have short follow-up periods.
  • The effectiveness of psychedelics may not be generalizable to all populations, as current research often involves small, select groups.
  • The potential for psychedelics to be abused or misused outside of a therapeutic setting could lead to negative health outcomes.
  • The integration of psychedelic therapy into mainstream healthcare may require significant changes to current medical infrastructure and training.
  • The cost-effectiveness of psychedelic therapy compared to existing treatments for mental health conditions has not been thoroughly evaluated.
  • The placebo effect could play a significant role in the perceived effectiveness of psychedelic therapy, and more rigorous blinding methods may be needed in studies.
  • The ethical implications of using psychedelics, which can profoundly alter consciousness, need to be carefully considered, especially in vulnerable populations.
  • There may be alternative non-pharmacological ...

Actionables

  • You can educate yourself on the history and science of psychedelics by reading books and articles from credible sources. This will help you form an informed opinion and counteract the stigma fueled by misinformation. For example, reading "How to Change Your Mind" by Michael Pollan or accessing scientific journals through platforms like PubMed can provide a deeper understanding of the therapeutic uses of psychedelics.
  • Start a mindfulness or meditation practice to familiarize yourself with altered states of consciousness in a safe and controlled manner. This can give you a personal insight into some of the therapeutic benefits associated with psychedelic experiences, such as increased self-awareness and emotional processing, without using substances.
  • Eng ...

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#2319 - Rick Doblin

Psychedelics in Consciousness and Evolution

Psychedelics hold a significant place in discussions about consciousness and evolution, with their potential impact on cognitive development and social structures being widely debated and researched.

Psychedelics May Have Influenced Human Cognitive Evolution

Mckenna's "Stoned Ape" Theory: Psilocybin Use Aided Language and Brain Development in Early Humans

Joe Rogan and Rick Doblin delve into Terence McKenna's "Stoned Ape" theory, proposing that early primate consumption of psilocybin mushrooms led to elevated consciousness, contributing to the development of language and brain growth. The theory explains the doubling of the human brain size, positing that as rainforests transformed into grasslands, the resulting increase in mushrooms consumed by primates improved visual acuity, promoted amorous behavior, and increased creativity. This chain reaction could have led to advanced hunting skills, better nutrition, and ultimately, robust brain evolution.

Psychedelics Enhance Interconnectedness and Broaden Perspectives, Impacting Society and Spirituality

Psychedelics are said to deepen the sense of interconnectedness among individuals, influencing society and spirituality. Rick Doblin speaks on the essence of the spiritual aspects of psychedelics, emphasizing the potential role they could play in elevating human consciousness. He recounts his dream where a dying man stressed that studying psychedelics is crucial for feeling interconnectedness, making it less likely for people to dehumanize each other.

Psychedelics Address Challenges Through Expanding Consciousness

Psychedelics Foster Shared Humanity, Reducing Tribalism and Conflict

Rogan and Doblin discuss how psychedelics could foster a cultural shift away from conflict by promoting a sense of shared humanity. In his conversation with Doblin, Rogan discusses the contributions of groups like Combatants for Peace, consisting of former Israeli soldiers and Palestinians who now advocate for nonviolence. Research by Lior Roseman demonstrated how ayahuasca sessions impacted Israelis and Palestinians, allowing them to appreciate their commonality and recognize each other's pain. Doblin speaks to the reduction of tribalism through an understanding of interconnectedness, offering perspectives on DNA similarities among all life and how this recognition can lead to ...

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Psychedelics in Consciousness and Evolution

Additional Materials

Clarifications

  • Terence McKenna's "Stoned Ape" theory suggests that early human ancestors consuming psilocybin mushrooms led to enhanced cognitive abilities, potentially influencing the development of language and brain growth. The theory proposes that the consumption of these mushrooms could have contributed to the expansion of human consciousness and played a role in the evolution of the human brain. This hypothesis links the consumption of psychedelics to increased visual acuity, creativity, and social behaviors, which may have had a significant impact on human cognitive evolution. The "Stoned Ape" theory offers a perspective on how psychedelics could have played a part in shaping the cognitive development of early humans and their societal structures.
  • Psychedelics, such as psilocybin, are believed to deepen the sense of interconnectedness among individuals by altering perception and cognition. This altered state of consciousness can lead to a feeling of unity with others and the environment, fostering empathy and compassion. Many individuals report spiritual experiences while under the influence of psychedelics, feeling connected to something greater than themselves and experiencing a sense of transcendence. These spiritual experiences can have a profound impact on one's worldview and understanding of interconnectedness in the universe.
  • Psychedelic insights have been suggested to trigger a transformative shift in thinking, potentially offering new perspectives and solutions to complex global issues like nuclear war and climate change. By altering consciousness and promoting interconnectedness, psychedelics may encourage a more holistic and empathetic approach to these challenges. This "new mode of thinking" could inspire innovative strategies and foster a deeper sense of shared humanity, leading to more effec ...

Counterarguments

  • The "Stoned Ape" theory is speculative and lacks direct empirical evidence; it is not widely accepted in the scientific community as a significant factor in human evolution.
  • The effects of psychedelics on interconnectedness and spirituality are subjective and can vary greatly between individuals; they are not universally experienced or interpreted in the same way.
  • While psychedelics may reduce tribalism and conflict in some contexts, they are not a panacea for deeply rooted social and political issues and could potentially exacerbate certain mental health conditions in some individuals.
  • The idea that psychedelics can induce a "new mode of thinking" capable of addressing global challenges is optimistic and may overlook ...

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