In this episode of The Diary Of A CEO, experts Vonda Wright, Mary Claire Haver, Natalie Crawford, and Stacy Sims discuss women's health, exercise, and longevity. The conversation examines the crucial role of muscle mass in women's health, exploring how strength training benefits everything from bone density to brain function. The experts also address how women can optimize their exercise routines based on their menstrual cycles and hormonal changes.
The discussion extends beyond exercise to cover comprehensive aspects of women's health throughout different life stages. Topics include the effects of environmental toxins on reproductive health, the importance of proper nutrition and protein intake, the impact of sleep quality, and the role of supplements like creatine. The experts also examine specific considerations for perimenopausal and menopausal women, including the benefits and timing of hormone replacement therapy.

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Experts Vonda Wright, Mary Claire Haver, and Natalie Crawford emphasize that muscle mass is crucial for women's health and longevity. According to Wright, muscle helps produce brain neurons, while Crawford notes its importance in fighting [restricted term] resistance and inflammation. Haver warns about the osteoporosis epidemic among women, highlighting how muscle mass directly correlates with stronger bones.
The experts recommend adjusting exercise routines based on menstrual cycles. Stacy Sims explains that women often feel strongest around days 6-14 of their cycle when estrogen levels are high, making it an ideal time for intense training. However, Crawford emphasizes the importance of listening to one's body rather than following rigid guidelines.
Regarding strength training, Sims advocates for heavier weights over moderate-intensity cardio, noting its superior benefits for muscle building and bone density. The LIFT-MORE study shows that even elderly women with osteoporosis can safely benefit from supervised heavy weightlifting.
A diet rich in protein, fiber, and healthy fats is essential for building muscle and maintaining hormonal balance. Sims recommends a plant-forward diet, particularly for perimenopausal women, while incorporating moderate amounts of red meat and healthy fats from sources like olive oil and nuts.
The experts caution against intermittent fasting for women. Haver notes the difficulty of meeting protein goals while fasting, and Sims warns that fasting can disrupt hormonal balance. Crawford adds that fasting may lead to increased visceral fat storage and inflammation.
As women approach menopause, their nutritional needs change. Haver emphasizes the increasing importance of protein intake with age, particularly for preventing frailty. The experts stress the need for anti-inflammatory nutrition choices during perimenopause.
Crawford discusses how environmental toxins, particularly endocrine disruptors like BPA, can accelerate reproductive aging and lower ovarian reserve. She recommends practical steps to reduce exposure, such as avoiding plastic containers for hot foods, using clean cookware without non-stick surfaces, and filtering water.
Sims emphasizes that quality sleep is non-negotiable for women's health, affecting everything from metabolism to fertility. Sleep disruption is particularly common during perimenopause and menopause, as explained by Crawford and Haver, often due to hormonal changes and symptoms like hot flashes.
The experts recommend several key supplements for women's health. Wright suggests vitamin D, magnesium, omega-3s, and creatine. Sims explains that creatine particularly benefits women, who typically have lower stores, supporting brain, heart, gut, and muscle function. For menopausal women, Wright emphasizes the benefits of monitored hormone therapy for protecting bone density, while Haver cites the LIFT-MOORE trial showing enhanced results when combining hormone replacement therapy with resistance training.
1-Page Summary
Experts like Vonda Wright, Mary Claire Haver, and Natalie Crawford emphasize the critical benefits of muscle mass for women's health and longevity.
Vonda Wright points out that muscle helps your brain produce more neurons which is essential for brain health, and Natalie Crawford adds that building muscle is important for combating [restricted term] resistance and inflammation. This is especially significant for women with conditions like PCOS or endometriosis. Muscle is a metabolic organ essential for glucose metabolism and [restricted term] sensitivity, also playing a role in neuron production and affecting satiety.
Mary Claire Haver alerts to the osteoporosis and frailty epidemic among women, stating that a significant percentage will have low bone density, and a large share of hip fractures occur in women. Estrogen impacts muscle protein synthesis and is a strong anti-inflammatory, which is crucial for combating chronic inflammation that can decrease muscle and bone synthesis. The amount of muscle a woman has directly correlates with stronger bones, which are vital for locomotion and support.
Wright also describes the importance of building bone density while estrogen levels are still high, elucidating on estrogen's role in balancing bone mineral density. As women age, the importance of muscle mass increases due to estrogen levels dropping, intensifying the need to combat [restricted term] resistance and maintain glucose metabolism. It is noted that both muscle strength and bone health are key to avoiding frailty and becoming immobile.
Haver likens muscle to one of the most geroprotective organs and emphasizes its importance, particularly when ovaries are no longer functional due to aging.
Adjusting exercise regimens to the menstrual cycle is essential, as hormonal fluctuations can influence energy levels and workout effectiveness.
Stacy Sims discusses the impact of perimenopause on muscle function and the influence of estrogen on muscle contraction. She explains that lifting heavier loads can compensate for myosin dysfunction, providing an essential external stimulus for maintaining strong muscle contractions, irrespective of estrogen levels.
Crawford and Sims advise women to adapt their exercise based on their current state and menstrual phase, acknowledging that it's okay for activities to vary. For instance, many women experience increased energy before ovulation, making it a good time for heavier weights or more reps. Sims recommends prioritizing high-intensity training and heavier lifting for days when women feel at their best. She points out that women often feel their strongest around days six to 14 of their cycle when estrogen levels rise.
On the other hand, women's responses to ovulation can differ, with some experiencing significant pain during ovulation, which affects their ability to be physically active. Furthermore, the luteal phase can be variable for different women, which might impact their ability to hit certain training metrics.
Crawford stresses the importance of listening to one's own body and understanding personal responses rather than adhering to blanket statements about exercise across menstrual cycles. Wright stresses that women with profound periods of low estrogen are at risk for severe problems with their bone density and should get bone scans earlier to determine proper treatment.
Strength training plays a pivotal role in women's health, especially in building muscle and improving bone density.
Discussing the importance of heavier strength training, Sims notes that this builds muscle, improves bone density, and optimizes health, contrasting it to the minimal benefits of moderate-intensity cardio. S ...
Women's Exercise and Strength Training
Experts Natalie Crawford, Stacy Sims, and Mary Claire Haver provide insight into the complex relationship between nutrition, fasting, and hormonal health for women at different stages of their lives.
Crawford and her colleagues emphasize that proper nutrition is crucial for not only day-to-day wellbeing but also for supporting extensive training. A diet rich in protein, fiber, and healthy fats is instrumental in building muscle, balancing hormones, and overall health. Sims suggests that a plant-forward diet is particularly beneficial for perimenopausal women. Sources such as olive oil, nuts, avocados, seeds, and some red meat, in moderation, are critical for hormonal health. The speakers advocate for the 80-20 rule to maintain a high-quality diet, and Crawford highlights the importance of fiber from fruits and vegetables for gut microbiome health and reducing inflammation.
Haver has evolved in her thinking about fasting for women, observing that meeting protein goals while fasting can be challenging, potentially impacting body composition and health span. Sims describes differences between intermittent fasting and time-restricted eating, cautioning against fasting patterns like water fasts that may disrupt hormonal balance, especially for women. Crawford adds that practices like fasting could negatively impact hormonal health, while Haver outlines concerns of fasting leading to visceral fat storage and pro-inflammatory states. Long periods of fasting are stressful for women at a cellular level, potentially causing the body to enter a perceived state of starvation and disrupting the hypothalamus.
As women approach menopause, there is a significant decrease in gut microbiome diversity, which is closely related to ...
Women's Nutrition, Fasting, and Hormones
Steven Bartlett and Natalie Crawford discuss the effects environmental toxins have on women's health, highlighting the potential damages to reproductive health and overall well-being.
Natalie Crawford emphasizes the detrimental effects of endocrine disrupting chemicals, like BPA, which are found in plastics, cosmetics, food, and even thermal receipt paper. These toxins can disrupt hormonal functions and cause ovarian issues. BPA, in particular, has been linked with a lowered ovarian reserve—the number of eggs a woman has—which can lead to an earlier onset of menopause. Exposure to such chemicals is associated with lower egg counts at a younger age.
Crawford delves into how toxins affect various health aspects including inflammation, hormones, metabolism, and cognition. She points out that the sum of all negative behaviors and exposures can lead to a pro-inflammatory state, affecting one's immediate and future health. Daily use of products such as highly scented handwash could slowly lead to endocrine disruption. Moreover, emotional stress and chronic emotional stress contribute to chronic inflammation which detrimentally affects the ovaries.
To mitigate the impact of toxins, Crawford recommends lifestyle changes. She advises again ...
Environmental Toxins and Their Impact on Women's Health
Understanding the relationship between sleep and women's health is critical. Experts underline that quality sleep is not just beneficial but essential for women's overall wellbeing.
Stacy Sims emphasizes the non-negotiable nature of sleep, stating without adequate sleep, women cannot achieve desired metabolic or body composition changes. Not only does sleep improve stress resilience, but it sets the health foundation for the entire day. Sims warns that starting the day with a sleep deficit can lead to stress, inflammation, and [restricted term] resistance. Moreover, women who get less sleep exhibit higher rates of infertility, further highlighting the influence of sleep on hormonal balance and reproductive health.
Poor sleep has a domino effect on various aspects of women's health, disturbing hormones, metabolism, immunity, and cognition. Phase shifting and creating stress on a circadian level can result in poor sleep, metabolic dysfunction, and altered circadian rhythms. Sleep serves as the most regenerative period, pivotal for brain processing and bodily detox. Sims illustrates this by mentioning the use of glucose monitors to investigate sleep issues related to the hypoglycemic effects in women who exercise but may not eat enough, implying a direct link between diet, metabolic health, and sleep quality.
Perimenopause and menopause are significant stages in a woman's life that often come with sleep disruption due to hormonal changes. Many women in midlife experience disrupted sleep patterns as estrogen, which is critical for regulating sleep, diminishes. A common phenomenon is women waking up around 3:37 a.m., potentially due to dropping blood sugar levels or sleep cycle interruptions.
Natalie Crawford suggests preparing for life stages like menopause, which can alter health and sleep patterns. Additionally, Mary Claire Haver explains how menopause can cause women to wake up due to hot flashes and night sweats and underscores the importance of assessing sleep apnea in women, as they may exhibit different symptoms than men.
The loss of the relaxation that progesterone provides in menopause can exacerbate sleep issues, even after using interventions like melatonin or hormones. When such methods fail to maintain sleep throughout the night, further evaluation for conditions such as sleep apnea might be necessary.
Appropriate sleep hygiene practices are vital for mitigating sleep issues in women. Strategies i ...
Sleep and Its Role in Women's Health
Experts discuss the role of key supplements in supporting women's health and longevity, emphasizing the importance of a comprehensive approach that includes nutrition, exercise, stress management, and, where appropriate, exogenous hormones.
Stevens Bartlett mentions that creatine is beneficial beyond the realm of bodybuilding, a fact supported by Stacy Sims who explains creatine's role in fast energy processes including those in the brain, heart, gut, and muscles, noting that women typically have lower creatine stores. A supplement dose of three to five grams daily can help saturate these tissues. Creatine also aids in faster recovery from brain trauma, decreases symptoms in IBS, and combats fatigue.
According to Dr. Vonda Wright, women should consider supplementing Vitamin D and magnesium for metabolic functions, Omega-3s for anti-inflammation, and Creatine for energy pathways. For overall energy in the body, supplementing with NMN or NR, which are B vitamin precursors to NAD+, is suggested.
Research supports a higher protein intake, particularly for active individuals. Increased protein can lead to improved body composition, as a study showed women increased muscle quality and reduced body fat by consuming 1.6 grams of protein per kilogram of body weight.
For fiber, the best source is from food. However, if a woman's dietary profile suggests otherwise, fiber supplements may be beneficial. Folic acid is essential for brain development and the prevention of neural tube defects. Given the less consumption of fortified foods, folic acid supplementation becomes crucial, especially in the context of fertility.
Wright stresses the benefits of exogenous estrogen in monitored hormone therapy, especially for menopausal women, to protect against rapid bone density loss associated with estrogen decline. The hormone therapy should be undertaken for around ten years to be effective.
Mary Claire Haver highlights the LIFT-MOORE trial's findings that a combination of hormone replacement therapy (HRT) and resistance training significantly improved bone density compared to resistance training alone. She advocates for getting baseline bone density measurements earlier than standard guidelines recommend, even if that means paying out of po ...
Supplements For Women's Health Across Lifespan
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