On The Diary Of A CEO, Steven Bartlett and experts in women's health explore the complexities of menstrual cycles, hormonal conditions, and fertility. The discussion covers how various factors can disrupt hormonal communication, the importance of tracking menstrual cycles, and the relationship between conditions like PCOS and endometriosis with fertility. The experts also address pregnancy loss and the significant physical and emotional effects of hormonal changes.
The conversation extends to perimenopause and menopause, including common symptoms and treatment options like hormone replacement therapy. The experts examine how lifestyle factors such as chronic stress and inflammation affect women's hormonal health, and discuss workplace policies that impact women during key life transitions. Throughout the episode, they emphasize the importance of early detection and proper medical attention for menstrual health issues.

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Stacy Sims and Natalie Crawford discuss the complexity of menstrual cycles and how various factors can disrupt hormonal communication. Crawford emphasizes that irregular cycles may indicate conditions like PCOS or endometriosis, particularly common among female athletes. They stress that severe menstrual pain shouldn't be dismissed as normal, as it could signal serious conditions requiring medical attention.
Tracking menstrual cycles is crucial for identifying concerning patterns early. As Liv's story demonstrates, dismissive treatment of severe menstrual pain can lead to delayed diagnoses of conditions like endometriosis, which Crawford describes as an inflammatory condition causing scarring and organ adhesion.
The experts explain how fertility significantly declines with age, especially after the mid-30s. Natalie Crawford notes that egg freezing, optimally done in the late 20s or early 30s, can help preserve fertility for those delaying childbearing. Conditions like PCOS and endometriosis can complicate fertility, as Mary Claire Haver shares from her personal experience with PCOS.
Pregnancy loss, while common, remains stigmatized. Crawford and Haver discuss how miscarriage can cause significant physical and emotional turmoil due to hormonal changes. They emphasize the importance of investigating contributing factors in recurrent pregnancy loss, including conditions like celiac disease and lifestyle factors such as chronic stress.
Vonda Wright and Mary Claire Haver explain that perimenopause symptoms can begin as early as age 35, including sleep disruptions, mental health challenges, and cognitive difficulties. Wright describes using a combination of hormones and lifestyle changes for management, while Haver discusses the benefits of low-dose estrogen during perimenopause.
Menopause, occurring at an average age of 51-52, varies widely among individuals. Haver explains that hormone therapy can effectively manage symptoms and reduce health risks. Despite its benefits, only 4% of eligible women in the U.S. use FDA-approved hormone therapy, largely due to stigma and lack of education.
The experts emphasize how chronic inflammation and [restricted term] resistance affect women's hormonal health. Crawford points out that chronic stress impacts fertility, while Haver explains how metabolic dysfunction relates to conditions like PCOS. They advocate for tailoring lifestyle habits to different phases of the menstrual cycle for optimal health and performance.
The discussion concludes with workplace considerations, noting how traditional work structures often fail to accommodate women during key life transitions. The speakers highlight more progressive policies in places like New Zealand, which offers menstrual and menopause leave to support women's health needs.
1-Page Summary
Experts in the field of women's health emphasize the importance of menstrual cycle awareness and understanding the potential indications of hormonal conditions such as PCOS and endometriosis.
Stacy Sims discusses the historical acceptance of amenorrheic women in sports, an incorrect association with a more male-like and therefore acceptable condition. Natalie Crawford and Sims imply that an understanding of hormones and their variation is critical, noting a complexity that can make diagnosis challenging. Additionally, lifestyle factors can affect menstrual regularity, as Steven Bartlett describes his partner's more regular menstrual cycle after a diet change.
Progesterone builds a lush endometrial lining affecting glycogen storage, explaining different exercise responses depending on ovulation. Sims stresses reviewing stressors in the allostatic load when menstrual cycles falter, suggesting diet or recovery adjustments. Estrogen, responsible for growing the uterine lining, can indicate hormonal balance by menstrual flow, with lighter bleeds suggesting less exposure.
Crawford argues that consistent menstrual cycles are normal, and irregularities may signal underlying conditions such as PCOS, endometriosis, or hormonal imbalances. Stacy Sims points out that PCOS is more common among successful female athletes and that careful management of training and nutrition can help avoid oral contraceptives, which might affect performance. Crawford underlines the importance of menstruation for non-contraceptive-using women of reproductive age, linking the absence of periods to detrimental bone and brain health due to low estrogen levels.
Crawford indicates that 50% of patients with unexplained infertility may have endometriosis, a condition difficult to diagnose. She argues for addressing the root causes of menstrual pain, rather than treating symptoms with birth control pills. Excruciating menstrual pain could point to endometriosis, adenomyosis, or uterine fibroids.
Liv's journey illustrates the commonality of dismissive treatment towards severe menstrual pain, leading to delayed diagnoses. Endometriosis is an inflammatory condition where cells similar to the endometrial lining implant and cause inflammation elsewhere in the body, leading to scarring and organ adhesion. Despite treatments that offer symptomatic relief, the disease is not reversible and has severe impacts on mental health and fertility. Sims reports that cold w ...
Menstrual Cycle Health and Hormonal Conditions
Steven Bartlett and experts like Mary Claire Haver and Natalie Crawford explore the complexities surrounding fertility, the increasing challenges of conception with age, and the often stigmatized topic of pregnancy loss.
Women experience a significant decline in the quantity and quality of their eggs as they age, particularly after their mid-30s, affecting their ability to conceive.
Given the challenges associated with aging eggs, technology such as egg freezing offers an opportunity to preserve fertility. Bartlett’s discussion with his girlfriend about whether to freeze their eggs, and the experiences of women over 35, underline the importance of planning for the future. Natalie Crawford notes that the optimal time for egg freezing is in the late 20s or early 30s due to better egg quality. Crawford also refers to the increase in egg freezing when insurance covers the costs, demonstrating the significance of access and financial resources in fertility decisions.
Conditions like PCOS and endometriosis are linked to infertility and warrant careful consideration when planning for a family. Crawford highlights insufficient research and funding for such conditions, and Haver shares her challenging journey to conception due to PCOS. Surgery for endometriosis and the use of birth control for PCOS management are interventions that influence fertility. With endometriosis and PCOS, individuals may need to confront fertility and conception decisions earlier than expected.
Pregnancy loss, whether referred to as miscarriage or by another term, is a frequent but often hidden and emotionally challenging experience.
Crawford and Haver bring attention to the deep emotional effects of pregnancy loss, an experience t ...
Fertility, Pregnancy, and Pregnancy Loss
Steven Bartlett brings up menopause, sparking a discussion on the importance of understanding hormones to manage menopause symptoms and health risks.
Vonda Wright and Mary Claire Haver share insights into perimenopause, emphasizing that symptoms can start as early as age 35, even with regular menstrual cycles.
Mary Claire Haver discusses symptoms like sleep disruptions, mental health challenges, and cognitive changes that women often face during perimenopause, which can be alarming to high-functioning individuals. Wright remarks on symptoms such as heart palpitations, night sweats, and brain fog. The cognitive difficulties during perimenopause are concerning for women as they may forget simple things, such as where their keys are, or struggle to recall names. Natalie Crawford is on low-dose estrogen to alleviate the effects of perimenopause, even though she is still cycling regularly.
Haver suggests using low doses of estrogen in perimenopause seems beneficial against certain mental health conditions, potentially more so than increasing SSRIs. Wright herself chose to use a combination of [restricted term], progesterone, and [restricted term], paired with lifestyle changes for optimal health.
Defined as one year after the final menstrual period, the average age of menopause is 51 to 52, when the ovaries fail and cease to produce eggs and hormones.
Haver describes menopause as varying widely among individuals, highlighting the necessity for a broader understanding of women's health that encompasses the years beyond reproductive capability. She illustrates the personal significance of deciding to start menopause hormone therapy and discusses the mental health benefits of using hormone therapy early in perimenopause. Hormone therapy options include various forms, such as estrogen, progestogens, [restricted term], and different delivery systems.
Haver is on a hormone therapy regimen that includes a patch and oral [restricted term], oral micronized progesterone, and a [restricted term] gel that is FDA approved for men. Post-menopause, women stabilize hormonally, which may explai ...
Perimenopause, Menopause, and Hormone Replacement Therapy
Significant discussion by various speakers sheds light on the key lifestyle factors that play a role in women's health, specifically their hormonal, reproductive, and overall well-being. The conversations reveal the intricate connections between these factors and the importance of considering women's unique physiological needs.
Mary Claire Haver, Natalie Crawford, and others discuss the crucial role of [restricted term] resistance and chronic inflammation in women's hormonal health. Crawford points out that chronic stress impacts natural fertility and the success of IVF treatments. Haver notes that metabolic dysfunction, often seen in conditions like PCOS, is a symptom of the body's response to high [restricted term] levels. She also explains the importance of exercise for health and as a proactive measure to avoid health issues later in life. Additionally, Haver mentions that PCOS and endometriosis can accelerate the detrimental effects of chronic inflammation and [restricted term] resistance, highlighting the importance of engaging in anti-inflammatory diets and managing stress levels.
Lifestyle mechanisms that improve hormonal health often target these two factors, enhancing systemic health. [restricted term] resistance can lead to higher blood glucose levels and, consequently, perpetuate a cycle of hormonal imbalance. The panel underscores how lifestyle factors, including proper nutrition and exercise, can influence the severity of [restricted term] resistance-related conditions like PCOS and its accompanying symptoms.
The discussion reflects on the need for women to tailor their lifestyle habits, such as diet and exercise, to different phases of their menstrual cycle to optimize health and performance. Sims comments on the inaccuracies caused by wearable devices that fail to track physiological changes accurately, especially during the luteal phase. This might cause women to doubt their capabilities due to misinterpreted data. She advocates for the comparison of physiological data across identical phases of consecutive menstrual cycles. The speakers also emphasize the importance of considering the menstrual cycle as more than a reproductive function; it affects all parts of female physiology, underscoring the need for lifestyle modifications tailored to menstrual patterns to optimize health.
The speakers pr ...
Lifestyle Factors and Their Impact on Women's Health
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