Podcasts > The Diary Of A CEO with Steven Bartlett > Addiction Doctor: Alcohol Rewires Your Brain! Alcohol Is The Reason You Feel Awful! This Many Glasses Of Wine Increases Cancer Risk By 40%!

Addiction Doctor: Alcohol Rewires Your Brain! Alcohol Is The Reason You Feel Awful! This Many Glasses Of Wine Increases Cancer Risk By 40%!

By Steven Bartlett

In this episode of The Diary Of A CEO with Steven Bartlett, addiction specialist Sarah Wakeman challenges common beliefs about alcohol consumption and its effects on health. She explains how alcohol impacts various body systems, from increasing cancer risk by 40% with just two glasses of wine per day to causing brain shrinkage and heart conditions. Wakeman also describes how alcohol hijacks the brain's reward system and discusses the genetic components of addiction risk.

The conversation explores effective addiction treatment approaches, contrasting evidence-based methods with traditional rehabilitation programs. Wakeman and Bartlett examine how societal factors like isolation and loneliness contribute to addiction, while discussing the importance of strong communities in prevention and recovery. They also address the need for broader societal changes, including improved access to mental health resources and reduced stigma around addiction.

Addiction Doctor: Alcohol Rewires Your Brain! Alcohol Is The Reason You Feel Awful! This Many Glasses Of Wine Increases Cancer Risk By 40%!

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Addiction Doctor: Alcohol Rewires Your Brain! Alcohol Is The Reason You Feel Awful! This Many Glasses Of Wine Increases Cancer Risk By 40%!

1-Page Summary

Health Effects of Alcohol and Science Behind Addiction

Sarah Wakeman challenges the common belief that moderate alcohol consumption can be protective, explaining that even modest drinking increases the risk of various cancers. She notes that just two glasses of wine daily can increase cancer risks by 40%. When alcohol metabolizes in the liver, it creates toxic byproducts that cause cell damage and inflammation. This damage is particularly severe when combined with smoking, as the risks multiply rather than simply add together.

Beyond cancer risks, Wakeman describes how heavy alcohol use can lead to brain shrinkage and dementia-like symptoms, as revealed by MRI scans. The effects extend to heart health, potentially causing conditions like atrial fibrillation and congestive heart failure.

Regarding addiction's neurobiology, Wakeman explains how substances hijack the brain's natural reward system through [restricted term] release, creating a pleasure loop that leads to cravings. The risk of developing addiction is 40-60% genetic, similar to diabetes, with trauma and early childhood experiences playing significant roles in susceptibility.

Challenges and Approaches To Treating Addiction

Wakeman criticizes traditional rehab programs for their lack of long-term support and their tendency to treat addiction as a moral failing rather than a medical condition. She advocates for evidence-based treatments, including cognitive behavioral therapy and medication, which are often underutilized due to stigma.

In terms of treatment approaches, Wakeman emphasizes the effectiveness of motivational interviewing, which focuses on a person's intrinsic reasons for change rather than external demands. She warns against confrontational tactics and "tough love" approaches, noting that therapists lacking empathy can actually worsen their clients' substance use.

Societal Factors That Contribute To Addiction

Wakeman and Bartlett discuss how isolation and loneliness fuel addiction, emphasizing that strong communities and relationships can serve as protective factors. They reference the Rat Park experiments to illustrate how engaging environments and social connections impact addiction outcomes.

The discussion extends to the importance of upstream prevention, with Wakeman highlighting the need to address broader societal issues like untreated mental illness and trauma. She advocates for early interventions, including affordable housing and community resources, to build resilience against addiction. The hosts emphasize the importance of changing language around addiction to reduce stigma and increase empathy, promoting person-first language that facilitates healing rather than judgment.

1-Page Summary

Additional Materials

Clarifications

  • The Rat Park experiments were a series of studies conducted in the late 1970s to explore drug addiction in rats. The experiments focused on how living conditions and social interactions influenced drug consumption behaviors. Rat Park provided a more enriched environment for the rats compared to traditional laboratory settings, aiming to understand addiction beyond just the drug itself. The results suggested that improved living conditions and social interactions in Rat Park reduced the rats' consumption of morphine, challenging previous findings based on solitary and austere housing conditions.
  • Person-first language emphasizes describing individuals by their humanity before mentioning any conditions or traits they may have, aiming to prevent dehumanization and marginalization. It prioritizes recognizing the person first and foremost, rather than defining them solely by a particular characteristic. This approach is commonly used when discussing individuals with chronic illnesses, disabilities, or other conditions to promote respect and dignity. Person-first language is about acknowledging the individual beyond their condition, focusing on their personhood before any labels.

Counterarguments

  • While moderate alcohol consumption has been linked to increased cancer risks, some studies have suggested that the relationship between alcohol and health outcomes may be more complex, with factors like drinking patterns and individual genetics playing a role.
  • The liver's ability to metabolize alcohol without creating harmful byproducts may vary significantly among individuals, suggesting that some people might be less susceptible to alcohol-related liver damage.
  • The synergistic effect of smoking and alcohol on health risks is well-documented, but it's also important to consider that not all individuals who drink also smoke, and vice versa, which can affect overall risk assessments.
  • The association between heavy alcohol use and brain shrinkage is clear, but there is ongoing research into the reversibility of such effects with sustained abstinence or moderate consumption.
  • While alcohol can affect heart health, the relationship is dose-dependent, and some studies have suggested that low to moderate alcohol consumption might have a protective effect on the heart for some individuals.
  • The genetic contribution to addiction risk is significant, but it's also important to consider the complex interplay between genetics and environment, which can influence the development of addiction.
  • Some traditional rehab programs have shown success for certain individuals, and while they may not incorporate the latest evidence-based practices, they can still be a valuable part of a multifaceted approach to addiction treatment.
  • Medication and cognitive behavioral therapy are important, but they may not be suitable or effective for everyone, and some individuals may benefit from alternative or complementary therapies.
  • Motivational interviewing is effective for many, but some individuals may respond better to different therapeutic approaches, including those with more structure or directiveness.
  • While confrontational tactics are generally not recommended, there may be specific contexts or individual cases where a more direct approach could be beneficial, provided it is delivered with care and professional judgment.
  • The role of societal factors in addiction is crucial, but individual agency and personal responsibility in the context of addiction should not be entirely discounted.
  • Upstream prevention is important, but it should be balanced with effective treatment options for those who are already struggling with addiction.
  • The emphasis on changing language around addiction to reduce stigma is valuable, but it is also important to ensure that this does not inadvertently minimize the seriousness of addiction or the harm it can cause.

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Addiction Doctor: Alcohol Rewires Your Brain! Alcohol Is The Reason You Feel Awful! This Many Glasses Of Wine Increases Cancer Risk By 40%!

Health Effects of Alcohol and Science Behind Addiction

Alcohol's Effects: Cancer Risk, Liver Damage, Brain Changes, and More

Sarah Wakeman raises concerns about the common misperception that alcohol can be protective against health harms. Contrary to this belief, even moderate drinking is linked with an increased risk of various cancers, including breast and esophageal cancer. She emphasizes that the amount of alcohol it takes to start causing health problems is much lower than most assume. Specifically, consuming alcohol above low-risk limits raises the risk for certain cancers, with drinking two glasses of wine daily leading to a 40% increase in health risks for some cancers.

Wakeman describes how alcohol metabolizes in the liver into toxic byproducts that float around, causing cell damage and inflammation, and, consequently, an increased cancer risk. This damage can be compounded in those who drink and smoke, as alcohol increases susceptibility to the carcinogens in tobacco, with the risks being multiplicative rather than merely additive. Moreover, if caught early, liver damage from alcohol can be reversible, but advanced conditions like cirrhosis can lead to irreversible damage.

Further extending alcohol’s reach, it affects not just the liver and cancer risk, but also has sobering effects on the brain. MRI scans reveal that heavy alcohol use can lead to significant brain shrinkage and dementia-like impairment over time. Ethanol's inflammatory and cellular effects on the brain can be exacerbated by common nutritional deficiencies among those with heavy consumption. High alcohol intake is also linked to heart issues, such as atrial fibrillation, also known as "holiday heart," and can contribute to congestive heart failure due to a weakened heart muscle.

Addiction Neurobiology: Substances Hijacking the Brain's Reward System

Addiction’s roots can be explored through the lens of neurobiology, where alcohol and other addictive substances release [restricted term] in the brain, neurochemically rewarding consumption and creating a pleasure loop. Over time, these substances induce changes in the brain that lead to cravings and an escalating need for the substance. Our natural reward system, which includes pleasure from exercise, food, sex, and connection, c ...

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Health Effects of Alcohol and Science Behind Addiction

Additional Materials

Clarifications

  • Alcohol is primarily metabolized in the liver by enzymes, specifically alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). ADH converts alcohol into acetaldehyde, a toxic byproduct, which is further broken down into acetate by ALDH. Acetaldehyde is highly reactive and can cause cellular damage and inflammation, contributing to various health risks, including an increased risk of cancer. The accumulation of acetaldehyde in the liver can lead to oxidative stress and damage to liver cells over time.
  • Alcohol consumption is linked to an increased risk of various cancers, including breast and esophageal cancer. The metabolism of alcohol in the liver produces toxic byproducts that can lead to cell damage and inflammation, raising the risk of cancer. Drinking above low-risk limits, such as two glasses of wine daily, can significantly increase the risk of developing certain types of cancer. Additionally, alcohol consumption can amplify the carcinogenic effects of tobacco, particularly when both substances are used together.
  • Low-risk limits for alcohol consumption are guidelines that suggest the maximum amount of alcohol one can consume without significantly increasing health risks. These limits vary by country but generally recommend lower levels of alcohol intake to minimize harm. They are based on research that shows a correlation between alcohol consumption and various health issues, such as liver damage and certain cancers. Staying within these limits is believed to reduce the negative impact of alcohol on health.
  • Heavy alcohol use can lead to brain shrinkage over time due to its toxic effects on brain cells and interference with the brain's normal functioning. This shrinkage can be observed through MRI scans, showing a reduction in brain volume and potential cognitive impairments. Chronic alcohol consumption can damage neurons, disrupt neurotransmitter levels, and lead to cognitive deficits and memory problems. The inflammatory and cellular effects of ethanol on the brain can contribute to structural changes and impairments in brain regions responsible for memory, learning, and decision-making.
  • Genetics plays a significant role in addiction risk, with about 40 to 60% of the risk attributed to genetic factors. This means that a person's genetic makeup can influence their susceptibility to developing an addiction. The comparison ...

Counterarguments

  • The assertion that even moderate drinking increases cancer risk may be contested by studies showing that the relationship between alcohol consumption and cancer risk is dose-dependent, with some research suggesting that very light drinking might not significantly increase cancer risk.
  • The claim that two glasses of wine daily lead to a 40% increase in health risks for some cancers might be challenged by pointing out that risk percentages can vary widely depending on individual genetics, lifestyle factors, and the type of alcohol consumed.
  • While alcohol metabolizes into toxic byproducts, some argue that the liver is capable of efficiently processing small amounts of alcohol without long-term damage, and that moderate consumption may not pose significant risks to liver health for individuals without preexisting conditions.
  • The reversibility of liver damage from alcohol might be more complex, with some experts suggesting that factors such as age, overall health, and the presence of other liver insults can influence the potential for recovery.
  • The link between alcohol and brain shrinkage could be nuanced by considering that not all individuals who consume alcohol heavily will experience significant cognitive decline, and other factors like genetics and overall lifestyle may also play a role.
  • The connection between alcohol and heart issues such as atrial fibrillation and congestive heart failure might be challenged by studies that have found moderate alcohol consumption to be associated with a lower risk of certain hear ...

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Addiction Doctor: Alcohol Rewires Your Brain! Alcohol Is The Reason You Feel Awful! This Many Glasses Of Wine Increases Cancer Risk By 40%!

Challenges and Approaches To Treating Addiction

The discussion on addiction treatment highlights the need for reframing societal perceptions of addiction and emphasizes evidence-based, compassionate approaches to support individuals in managing their addiction in the long term.

Traditional Rehab Limits and the Need For Evidence-Based, Compassionate Treatment

Rehab Programs Lack Long-Term Support For Addiction Management

Sarah Wakeman criticizes the traditional view of addiction as a moral failing and insists on viewing it as a medical condition requiring ongoing management, akin to living with a chronic illness like cancer. She describes the typical rehab approach, where the expectation is a "cure" after a short stay, as flawed. Rehab programs often lack long-term support, which is critical for ongoing recovery, and this lack is exemplified by missed opportunities for kindness and effective, science-backed care within the healthcare system.

Effective Addiction Treatments Underutilized

Wakeman points to the underutilization of evidence-based psychotherapies such as cognitive behavioral therapy and treatments for underlying trauma. Additionally, she underscores that medication treatments for conditions like alcohol use disorder are surrounded by stigma and misunderstanding, leading to their underuse. Subsequently, she emphasizes that it is often the treatment that fails the individual, rather than the individual failing treatment.

Empowering Sustainable Change Through Motivational Interviewing

Intrinsic Motivations Over External Demands

Wakeman underscores the importance of motivational interviewing, a technique that leverages a person's own reasons for change rather than external demands. It involves listening for "change talk," indicators that the person wants to change, and reflecting these back to amplify their significance, thereby steering clear of confrontation and argument.

Supportive Environment Focused On Personal Goals and Values

Wakeman also emphasizes the importance of a supportive environment focusing on personal goals and values, which aligns with CRAFT ...

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Challenges and Approaches To Treating Addiction

Additional Materials

Counterarguments

  • While reframing perceptions of addiction is important, it is also necessary to address the social and economic factors that contribute to addiction, such as poverty and lack of access to education and healthcare.
  • Evidence-based treatments are crucial, but there is also value in personalized approaches that may not have a strong evidence base yet due to the uniqueness of individual cases.
  • Long-term support is essential, but the effectiveness of different types of support can vary greatly among individuals, and some may benefit from less intensive, community-based support systems.
  • Viewing addiction as a chronic illness is helpful for many, but others may find that this perspective does not fully capture their experience or may feel it defines them by their addiction.
  • Cognitive behavioral therapy is effective, but it may not be suitable for everyone, and other therapeutic approaches may be more effective for certain individuals.
  • Medication treatments do face stigma, but it's also important to consider the potential for misuse and dependency on these medications themselves.
  • Motivational interviewing is a powerful tool, but it may not be effective for all individuals, and some may respond better to more directive or structured approaches.
  • The CRAFT ...

Actionables

  • You can start a book club focused on narratives about addiction to reshape perceptions within your social circle. Choose memoirs and novels that portray addiction as a chronic medical condition, and facilitate discussions that challenge stigma and promote empathy. For example, reading and discussing "The Night of the Gun" by David Carr can provide insight into the complexities of addiction and recovery.
  • Create a personal "recovery roadmap" that includes evidence-based strategies for managing addiction as a chronic illness. This might involve charting out a plan that incorporates regular check-ins with a therapist trained in cognitive behavioral therapy, setting up a medication management schedule if applicable, and identifying local support groups for long-term engagement. The roadmap could be visual, like a calendar or a chart, to help you stay on track and recognize the ongoing nature of recovery.
  • Develop a "motivation journal" where you regula ...

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Addiction Doctor: Alcohol Rewires Your Brain! Alcohol Is The Reason You Feel Awful! This Many Glasses Of Wine Increases Cancer Risk By 40%!

Societal Factors That Contribute To Addiction

Wakeman and Bartlett delve into the complex societal dynamics that contribute to addiction, emphasizing the role of social connection and the necessity of addressing the underlying causes through upstream prevention and empathy.

Isolation, Loneliness, and Lack of Connection Fueling Addiction

Wakeman points to the large scale of addiction worldwide, with stigma often leading to a lack of discussion on topics such as lack of connection and community. This is evidenced by stories of individuals needing to hit rock bottom before recognizing the need for change, suggesting that societal narratives around addiction emphasize disconnection and individual crises rather than support and community.

Social Disconnection and Individualism Increase Vulnerability To Addiction

Individuals struggling with addiction often feel hopeless, and a lack of perceived possibilities for a better life can contribute to the persistence of addiction. The hosts emphasize the importance of hope, love, empathy, and connection in facilitating change.

Strong Communities, Relationships, and Purpose Protect Against Addiction

Stories illustrate how isolation and loneliness play a central role in exacerbating addiction. For example, a man who became increasingly isolated and eventually died of an overdose represents the devastating impact of disconnection. Wakeman suggests that fostering connection can aid in addiction recovery, and Rat Park experiments underline the relevance of engaging environments and social connections. It has become evident that historically, human beings thrived on interconnectedness, with villages and multi-generational households providing support systems that are crucial in today’s context as well.

Building Resilience By Addressing Root Causes of Addiction Through Upstream Prevention

Wakeman emphasizes the importance of addressing broader societal issues such as untreated mental illness, trauma, and a fundamental lack of connection and purpose. Building resilience involves creating supportive environments early on, with affordable housing, community resources, and a foundation of strong relationships and attachments.

Investing In Early Childhood, Family Support, and Community Resources to Reduce Childhood Adversity

Discussion reflects on the powerful impact of adverse childhood ex ...

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Societal Factors That Contribute To Addiction

Additional Materials

Clarifications

  • The Rat Park experiments were a series of studies conducted in the late 1970s to explore drug addiction in rats. The experiments focused on how living conditions and social interactions influenced drug consumption behaviors in rats. The results suggested that providing rats with a more enriched environment reduced their consumption of morphine, highlighting the importance of social connection and environmental factors in addiction research. The Rat Park experiments challenged traditional views on addiction by emphasizing the significance of social context in understanding addictive behaviors.
  • Adverse Childhood Experiences (ACEs) are traumatic events occurring before age 18, such as abuse, neglect, or household dysfunction. These experiences can have long-lasting impacts on physical and mental health outcomes in adulthood. Understanding and addressing ACEs is crucial for preventing future health issues and promoting resilience in individuals who have experienced childhood trauma.
  • People-first language emphasizes describing individuals by their humanity before mentioning any conditions or traits they may have. It aims to prevent dehumanization and marginalization when discussing people with disabilities or chronic illnesses. This approach prioritizes seeing individuals as people first, rather than defining them by their conditions. Adv ...

Counterarguments

  • While social disconnection and individualism may increase vulnerability to addiction, it's also important to consider that addiction can occur in individuals with strong social ties and community support, suggesting that addiction is multifaceted and not solely a result of societal factors.
  • The emphasis on upstream prevention and addressing root causes is crucial, but it should not overshadow the need for effective treatment options for those who are currently struggling with addiction.
  • The role of genetics and biology in addiction is not addressed in the text, which is an important factor in understanding individual susceptibility to substance use disorders.
  • The concept of resilience can sometimes inadvertently place the responsibility for overcoming addiction on the individual, without fully acknowledging the systemic barriers that may impede access to resources and support.
  • The focus on changing language and attitudes to reduce stigma is important, but it must be paired with tangible policy changes and increased funding for addiction services to have a meaningful impact.
  • The narrative that strong communities and relationships protect against addiction might overlook the complexity of interpersonal dynamics and the fact that not all community or family environments are positive influences.
  • The idea that fostering connection aids in recovery is valuable, but it's also important to recognize that some individuals may ...

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