In this episode of The Diary Of A CEO, William Li discusses the body's natural defense systems against diseases like cancer and how these systems can be strengthened or weakened through diet and lifestyle choices. He explains how the body manages thousands of potential cancer-causing cell mutations daily and describes the role of processes like angiogenesis in preventing serious illnesses.
Li shares research on specific foods that can help fight disease, including tomatoes, berries, and various teas, while highlighting the negative impacts of processed foods, salt, sugar, and environmental factors like microplastics. The discussion covers the importance of the gut microbiome in disease prevention and explores how sleep patterns and intermittent fasting can optimize the body's natural defense mechanisms.
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William Li explains that our bodies are equipped with remarkable defense mechanisms against diseases like cancer. Every day, the body faces approximately 10,000 potential cancer-causing cell division mistakes, yet our immune system effectively manages these threats. Li compares this process to police patrols, constantly monitoring and addressing potential health concerns before they become serious issues.
These defense systems, including angiogenesis (blood vessel development) and immunity, are crucial for longevity and disease prevention. Li demonstrates this through his mother's case, where even at 80 years old, her weakened immune system could be rejuvenated to fight stage four cancer. He emphasizes that major diseases like heart disease, diabetes, and dementia are often linked to the breakdown of these defense systems over time.
Poor dietary choices can significantly weaken our body's defenses. According to Li, overconsumption of salt, sugar, alcohol, and processed foods can harm blood vessels, disrupt metabolism, and increase inflammation. Environmental factors, particularly microplastics, have been linked to increased risks of fatal heart attacks and strokes.
On the positive side, Li advocates for a plant-forward diet to boost the body's defenses. Specific foods like tomatoes, berries, and green tea have shown particular promise in bolstering natural defense mechanisms. These foods contain compounds that can prevent unnecessary blood vessel growth towards cancer cells and reduce inflammation throughout the body.
Li's research focuses on how specific foods can regulate angiogenesis to help prevent and fight disease. His experiments have shown that certain foods, such as cooked tomatoes, purple potatoes, and green tea, can effectively starve tumors by controlling blood vessel growth. English Earl Grey tea and matcha have demonstrated specific benefits for blood vessels and fighting cancer stem cells.
The gut microbiome plays a crucial role in these defense mechanisms. Li highlights research showing that a specific bacterium, Akkermansia muciniphila, is linked to improved cancer immunotherapy outcomes. Foods that promote this bacterium, such as pomegranates and chili peppers, may enhance the body's natural cancer-fighting abilities.
Regarding metabolism, Li explains that proper sleep is essential for fat burning and maintaining strong defense systems. He advocates for intermittent fasting as a way to optimize metabolism and burn excess fat, suggesting that a 16-hour fasting period can be achieved simply by skipping breakfast.
1-Page Summary
William Li discusses the body's remarkable ability to defend itself against diseases like cancer and the impact of lifestyle choices on these natural defense mechanisms.
According to William Li, every 24 hours, the body makes about 10,000 mistakes in cell division, any of which could potentially lead to cancer. He compares these potential cancers to pimples, noting that people are always forming these microscopic cancers from childhood. However, because of the body's defense systems, which function like a police cruiser patrolling a neighborhood, these microscopic issues do not typically turn into larger health concerns.
Li emphasizes that the body's immune system is constantly at work to stop these microscopic cancers, and it can be further ratcheted up through approaches like peptide vaccine treatments. He mentions clinical trials and a specific study in Nature Communications, where patients with glioblastoma saw extended cancer-free survival rates after immune-boosting treatments.
Li notes that devastating health consequences many people face today are partially due to past harms, including changes in food production and environmental degradation. He underscores that scientific advances are aiding in disease prevention and treatment, particularly regarding conditions such as diabetes and cardiovascular disease.
William Li expresses that his mother, even at the age of 80 with a weakened immune system, had defenses strong enough to be rejuvenated by immunotherapy to fight stage four cancer.
Eating the right foods and maintaining a healthy lifestyle can support natural defenses like angiogenesis—the development of new blood vessels, which is crucial for keeping tissues healthy and preventing harmful growths. These health defense systems, such as blood vessels and immunity, detect and eliminate microscopic cancers, and a failure in these systems can allow cancer to become a more significant threat.
When inflamed, visceral fat can interfere with normal organ function due to the compression it causes and the inflammation it spreads throughout the body, which is why maintaining the integrity of the body's defenses is crucial.
Body's Natural Defenses in Health and Disease Prevention
A strong relationship exists between diet, lifestyle, and the body's natural defenses, as explored by William Li and other experts in the field. Poor choices in diet and exposure to toxins can weaken our defenses, while a plant-forward diet can bolster them.
The way we live our lives, including our dietary habits and exposure to external factors, has a significant effect on our health defenses.
Overeating fast foods like burgers can compromise health defenses, with high levels of sodium accelerating cellular aging and impacting angiogenesis and circulation. William Li points out that sodium is a risk for hypertension and inflammation and sets up further health issues downstream. High blood sugar from an excess intake of added sugar leads to metabolism issues, marked by a blood glucose rise that challenges [restricted term] production. Alcohol over time can harm the brain, liver, and heart, likened to smashing a windshield when over-consumed.
Stress, in connection with diet, weakens the immune system, raises blood pressure, affects circulation, angiogenesis, and can even damage DNA. When combined with poor sleep, this leads to further complications like a foggy brain, an out-of-whack metabolism, and increased inflammation.
Unhealthy diets, especially those high in processed meats, are linked to a higher risk of colorectal cancer. Continuous overeating damages the metabolism, speeds up cellular aging, and establishes inflammation. A study indicates that excess body fat is tied to higher inflammatory markers in the bloodstream, fostering an environment conducive to cancer.
Concerns arise about environmental factors and their potential in compromising health defenses, particularly microplastics, associated with inflammation. Microplastics have been found throughout the human body and have been linked to a significant increase in the risk of fatal heart attacks or strokes. Li advises avoiding plastics where possible and lists specific actions like avoiding plastic cutlery.
A diet rich in certain plant-based foods can significantly enhance the body’s defense mechanisms.
Foods like strawberries and soy prevent unnecessary blood vessel growth towards cancer cells and diseased tissues. Foods that promote the growth of Akkermansia muciniphila, such as pomegranate juice, cranberries, chili peppers, and Chinese black vinegar, are linked to improved cancer immunotherapy outcomes.
Consistently choosi ...
Diet and Lifestyle's Impact on Defense Systems
William Li emphasizes the historical role of diet and lifestyle as medicine, and his research now applies modern science to determine which foods support the body's natural defenses. Angiogenesis, the growth of blood vessels, is a particular focus, as regulating this process can help starve tumors and support healthy tissue growth.
Li’s work in “food as medicine” revolves around understanding how certain foods can prevent disease and ties in with the body’s angiogenesis defense system.
Li’s experiments showed that certain foods have the ability to starve cancer cells by cutting off their blood supply. For example, men who regularly consume cooked tomatoes, rich in lycopene, have a lowered risk of developing prostate cancer. Tomatoes may regulate angiogenesis, thus starving tumors and killing cancer cells. Purple potatoes contain anthocyanins that have been shown in the lab to kill colon cancer stem cells. Other angiogenesis-regulating foods include green tea, onions, garlic, red grapes, strawberries, artichokes, and soy.
The Angiogenesis Foundation’s research found English Earl Grey tea to be particularly supportive of the body’s blood vessels. This fermented black tea combined with bergamot seems to have specific beneficial properties. Additionally, polyphenols in matcha tea have been found to kill breast cancer stem cells. The idea is that by preventing excessive growth of blood vessels towards cancer, these foods strengthen the body's defense systems and promote overall health.
Li stresses the importance of Akkermansia muciniphila, a bacterium linked to improved cancer immunotherapy outcomes. Research presented by Dr. Laurence Zitvogel indicated that cancer patients who responded well to immunotherapy had higher levels of this bacterium in their guts. Transferring the bacterium from human responders to non-responding mice restored the immune response against cancer in the mice. Li highlights the importance of foods known to promote Akkermansia in the gut, such as pomegranates and chili peppers. He also notes the potential of this probiotic to improve metabolism, reduce the risk of metabolic syndrome, and provide possible protection against dementia.
While no specific information on fasting and brown fat foods was provided, Li talks about the importance of sleep and its relationship with metabolism and body fat. During REM sleep, the metabolism shifts gears to burn fat. He emphasizes that proper sleep is crucial for burning away fat, while a lack of it leads to fat accumulation, inflammation, and weakened defense systems.
Li also discusses body fat and its types, where visceral fat poses significant health risks. Brown fat, different from wh ...
Foods and Nutrients: Potential to Support Defense Systems and Treat or Prevent Diseases
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