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The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!

By Steven Bartlett

In this episode of The Diary Of A CEO, scientist Nathan Bryan discusses the critical role of nitric oxide (NO) in regulating blood flow, oxygen delivery, and longevity. He explains how declining NO levels contribute to age-related chronic diseases like high blood pressure and diabetes.

The episode delves into factors impacting NO production, such as diet, oral hygiene, exercise, and light exposure. Bryan shares strategies to optimize NO levels, including eliminating inhibitors like mouthwash, nasal breathing, and potential NO supplements for those unable to boost levels through lifestyle changes.

The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!

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The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!

1-Page Summary

The Science and Importance of Nitric Oxide

Key Signaling Molecule For Blood Flow, Oxygen Delivery, and Regulation

According to Nathan Bryan, nitric oxide (NO) is vital for regulating blood flow, oxygen delivery, recovery processes, and longevity. It facilitates physiological functions like stem cell mobilization, energy production, and vascular dilation.

Nitric Oxide Decline With Age Linked To Chronic Diseases

Bryan states that as people age, they produce less NO, contributing to the onset of age-related chronic diseases. Lou Ignaro suggests restoring NO production could profoundly impact medicine.

Symptoms of Nitric Oxide Deficiency

Symptoms of low NO levels include erectile dysfunction, high blood pressure, exercise intolerance, and other conditions like diabetes and cognitive impairment. Bryan claims these symptoms are appearing earlier in life.

Factors That Impact Nitric Oxide Production

Diet Affects Nitric Oxide

Sugar and high-glycemic foods impair NO synthesis, linking high blood sugar to cardiovascular events, says Bryan. He recommends balanced proteins, fats, and minimal carbs to boost NO.

Oral Hygiene Impacts Nitric Oxide

Mouthwash, Fluoride Disrupt Oral Microbiome

Bryan connects antiseptics like mouthwash and fluoride to disrupting beneficial oral bacteria involved in NO production, potentially causing systemic issues.

Tongue Scraping Boosts Oral Microbial Diversity

In contrast, tongue scraping can maintain a diverse oral microbiome to support NO production if not combined with mouthwash.

Exercise and Light Stimulate NO

Exercise and sunlight/infrared light exposure activate the enzymes that synthesize NO, according to Bryan.

Strategies to Optimize Nitric Oxide Levels

Eliminate Nitric Oxide Inhibitors

Bryan advises against sugary foods, mouthwash, and antacids, as they inhibit NO production.

Boosting Nitric Oxide

Bryan suggests nasal breathing and humming at certain frequencies to stimulate NO synthase enzymes, contingent on proper enzyme function.

Nitric Oxide Supplements

For those unable to optimize levels through lifestyle changes, Bryan discusses potential NO supplements but cautions against overuse.

1-Page Summary

Additional Materials

Clarifications

  • Stem cell mobilization facilitated by nitric oxide involves the process where nitric oxide helps in the release of stem cells from the bone marrow into the bloodstream. This mobilization is crucial for various physiological functions and repair processes in the body. Nitric oxide plays a role in signaling pathways that regulate the movement and activity of stem cells in response to tissue damage or other physiological needs. This mechanism is essential for maintaining tissue homeostasis and supporting the body's regenerative capabilities.
  • Nitric oxide plays a role in energy production by supporting mitochondrial function. Mitochondria are known as the powerhouse of the cell, responsible for generating energy in the form of ATP. Nitric oxide helps regulate mitochondrial respiration and energy production processes within cells. This regulation is essential for various physiological functions, including cellular metabolism and overall energy balance.
  • Diet plays a crucial role in nitric oxide production. Consuming sugar and high-glycemic foods can hinder nitric oxide synthesis, while a balanced diet rich in proteins and healthy fats can help boost nitric oxide levels. Oral hygiene also affects nitric oxide production, with certain oral care products like mouthwash and fluoride potentially disrupting the oral microbiome involved in nitric oxide production. Conversely, practices like tongue scraping can help maintain a diverse oral microbiome that supports nitric oxide production.
  • Tongue scraping involves using a tool to clean the surface of the tongue, which can help remove bacteria and debris that contribute to bad breath and oral health issues. By maintaining a diverse oral microbiome through tongue scraping, beneficial bacteria that support nitric oxide production may thrive, potentially benefiting overall health. This practice is suggested as a way to promote oral hygiene and potentially enhance nitric oxide levels in the body. Tongue scraping is often recommended in conjunction with other oral care practices, like avoiding certain mouthwashes that may disrupt the oral microbiome.
  • Nasal breathing and humming can stimulate nitric oxide synthase enzymes by increasing airflow and promoting nitric oxide production in the sinuses. This process is believed to enhance oxygen exchange and circulation in the body, potentially benefiting overall health and well-being. The specific frequencies of humming may play a role in activating these enzymes, although more research is needed to fully understand the mechanisms behind this practice. Overall, nasal breathing and humming are suggested as natural methods to support nitric oxide levels in the body.

Counterarguments

  • While NO is important for health, the role of NO in longevity is complex and not fully understood; other factors also play significant roles in aging and chronic disease development.
  • The link between NO decline and chronic diseases is an association, and it is not always clear if NO decline is a cause or a consequence of these diseases.
  • The impact of restoring NO production on medicine is still an area of active research, and while promising, it should not be oversimplified as a cure-all approach.
  • The symptoms listed for low NO levels can have multiple causes, and it is important to consider a holistic approach to diagnosis and treatment rather than attributing them solely to NO deficiency.
  • The assertion that low NO symptoms are appearing earlier in life may require more epidemiological evidence to support the claim across diverse populations.
  • The relationship between diet and NO synthesis is complex, and while certain dietary patterns may influence NO levels, individual responses can vary greatly.
  • The role of oral hygiene in NO production is an emerging field of study, and while there is some evidence to suggest a connection, more research is needed to fully understand the implications and to develop best practices.
  • The recommendation to avoid mouthwash and fluoride to preserve NO production may conflict with their established benefits in dental health, and a balanced approach considering both oral health and NO production is necessary.
  • The benefits of tongue scraping for oral microbial diversity and NO production require more scientific validation.
  • While exercise and light exposure are known to have health benefits, the specific effects on NO production and the optimal types and amounts of exercise and light exposure for this purpose are still being studied.
  • The advice to eliminate certain foods and products as NO inhibitors should be personalized, as individual health conditions and responses can vary.
  • The suggestion to use nasal breathing and humming to stimulate NO production is interesting, but more research is needed to confirm the effectiveness and practicality of these techniques in the general population.
  • The use of nitric oxide supplements is a complex issue, and while they may benefit some individuals, they can also have side effects and interactions with other medications, necessitating careful consideration and medical supervision.

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The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!

The Science and Importance of Nitric Oxide

Nitric Oxide: Key Signaling Molecule For Blood Flow, Oxygen Delivery, and Regulation

Nathan Bryan and Steven Bartlett highlight the crucial role of nitric oxide (NO) as a signaling molecule vital for regulating blood flow, oxygen delivery, and recovery processes. According to Bryan, NO is foundational for human health and longevity and its production inside the body facilitates various physiological functions such as stem cell mobilization, energy production, and vascular dilation during exercise and sexual activity.

Bryan describes nitric oxide as a gas that is critical for several bodily processes and refers to it as the foundational longevity molecule due to its roles in activating the enzyme telomerase, protecting telomere length, signaling stem cell mobilization, and dictating the need for more efficient mitochondria. Bartlett supports these claims by touching on nitric oxide's relationship with longevity.

Nitric Oxide Decline With Age Linked To Chronic Diseases

As people age, their body's capacity to produce NO decreases. Bryan states that the loss of nitric oxide production is the earliest event in the onset and progression of age-related chronic diseases. This decline is now recognized as a significant factor in these conditions. Lou Ignaro, a Nobel Laureate, has suggested that restoring nitric oxide production could profoundly change medicine.

The hosts discuss how a lack of nitric oxide can lead to several chronic diseases. NO production ensures [restricted term] signaling; its absence causes resistance and subsequent diabetes. Similarly, the absence of NO signaling lowers the count and functionality of mitochondria. Insufficient NO production also leads to a decrease in circulating stem cells and the shortening of telomeres due to inactivation of telomerase.

Symptoms of Nitric Oxide Deficiency: Erectile Dysfunction, High Blood Pressure, Exercise Intolerance

Bryan notes that the first sign of NO deficiency is often erectile dysfunction, which is essentially an advanced form of cardiovascular disease. Without sufficient nitric oxide, blood vessels fail to dilate properly, which can increase blood pressure or lead to hypertension. Many hypertension drugs do not target NO production, which might exp ...

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The Science and Importance of Nitric Oxide

Additional Materials

Clarifications

  • Nitric oxide (NO) is a crucial signaling molecule in the body that regulates blood flow, oxygen delivery, and various physiological functions. It plays a key role in stem cell mobilization, energy production, and vascular dilation during activities like exercise and sexual activity. Additionally, NO is involved in activating enzymes, protecting telomeres, and maintaining mitochondrial efficiency. Its decline with age is linked to chronic diseases due to its impact on [restricted term] signaling, mitochondrial function, stem cell count, and telomere length.
  • Nitric oxide (NO) plays a role in activating the enzyme telomerase, which helps protect telomere length, the protective caps at the end of chromosomes. NO is also involved in signaling stem cell mobilization, which is the process of releasing stem cells from their reservoirs in the body for tissue repair and regeneration. These functions highlight the importance of NO in cellular health and longevity.
  • Nitric oxide deficiency can disrupt [restricted term] signaling, leading to [restricted term] resistance and potentially diabetes. Inadequate NO levels can impact mitochondrial function, reducing their count and efficiency. Additionally, low NO production can result in decreased circulating stem cells and telomere shortening due to telomerase inactivation. These effects highlight the importance of nitric oxide in maintaining various physiological functions related to metabolic health and cellular integrity.
  • Nitric oxide (NO) supplementation can be used topically to increase blood flow and combat infection in non-healing wounds. By applying NO directly to the affected area, it helps improve circulation and promote healing. This method leverages NO's role in vasodilation and its ability to enhance blood flow to the w ...

Counterarguments

  • While NO is important for many physiological functions, it is not the only molecule involved in these processes, and other factors also play significant roles in vascular health and longevity.
  • The direct causality between NO decline and the onset of chronic diseases may be more complex, with other contributing factors such as lifestyle, genetics, and environmental influences also playing critical roles.
  • The idea that restoring NO production could profoundly change medicine is an optimistic view, but it may be overly simplistic as chronic diseases are multifactorial and may require a more holistic approach to treatment and prevention.
  • The effectiveness of NO supplementation in treating various conditions, such as non-healing wounds, may vary among individuals, and more research may be needed to establish standardized treatment protocols.
  • The claim that NO deficiency is the first sign of erectile dysfunction being an advanced form of cardiovascular disease could be challenged by the fact that erectile dysfunction can have multiple causes, including psychological factors, which may not be directly related to NO levels.
  • The assertion that the future of medicine will depend on nitric oxide product technology may be too narrow, as advancements in m ...

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Factors That Impact Nitric Oxide Production

Understanding how various lifestyle factors can impact nitric oxide production is essential for maintaining cardiovascular health.

Diet Affects Nitric Oxide: Sugar and High-Glycemic Foods Impair Synthesis

Bryan explicates that sugar and high glycemic index foods hinder the body's ability to produce nitric oxide by preventing necessary changes to the nitric oxide synthesizing enzymes. He links high blood sugar, as seen in diabetics, with increased cardiovascular events due to this impairment.

Whole, Nutrient-Dense Foods Boost Healthy Nitric Oxide By Reducing Processed Carbs

Moving toward a diet lower in sugar and carbs, such as ketogenic or vegan/vegetarian diets, can benefit nitric oxide levels. Bryan advises a balanced intake of high-quality proteins, good fats, and minimal carbohydrates. However, he also acknowledges the practical difficulties people face when trying to change their diets to improve nitric oxide production.

Oral Hygiene, Microbiome, and Nitric Oxide Production Are Connected

Steven Bartlett and Nathan Bryan delve into oral hygiene's impact on the oral microbiome and nitric oxide production.

Mouthwash, Fluoride Toothpaste Disrupt Oral Microbiome and Nitric Oxide Availability

Bryan connects the use of antiseptics, like mouthwash and fluoride, to the disruption of beneficial oral bacteria. He notes that these substances could lead to systemic diseases. Specifically, mouthwash use can increase blood pressure by disrupting the oral microbiome that converts nitrates into nitric oxide.

On fluoride, he asserts that it is a neurotoxin that can have adverse effects on children's IQ and thyroid function. Bryan points to studies associating mouthwash use with increased blood pressure due to microbiome disruption and advises against using fluoride toothpaste or rinses.

Tongue Scraping Boosts Oral Microbial Diversity and Nitric Oxide but Sho ...

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Factors That Impact Nitric Oxide Production

Additional Materials

Counterarguments

  • While high-glycemic foods may impair nitric oxide synthesis, it's important to note that the body's response to these foods can vary greatly among individuals, and not everyone may experience significant impairment.
  • The relationship between high blood sugar and cardiovascular events is complex, and while impaired nitric oxide production may contribute, there are numerous other factors at play, such as inflammation and lipid profiles.
  • While ketogenic and vegan/vegetarian diets can benefit nitric oxide levels, they may not be suitable for everyone due to individual health conditions, nutritional requirements, or personal preferences.
  • A balanced intake of nutrients is important, but the optimal ratio of proteins, fats, and carbohydrates can vary widely among individuals, depending on factors like age, sex, activity level, and metabolic health.
  • The claim that mouthwash and fluoride toothpaste disrupt the oral microbiome and nitric oxide availability is controversial, and not all studies agree on this point. Some research suggests that mouthwash can be beneficial for oral health without significantly impacting nitric oxide production.
  • The characterization of fluoride as a neurotoxin is a contentious issue, with many health organizations supporting its use in toothpaste and water fluoridation as safe and effective for preventing dental caries.
  • While tongue scraping may boost oral microbial diversity, its ...

Actionables

  • You can create a personalized "Nitric Oxide Friendly" meal plan by incorporating foods known to enhance nitric oxide production, such as beets, garlic, leafy greens, and citrus fruits, while avoiding high-glycemic foods. For example, start your day with a spinach and citrus fruit smoothie, have a salad with garlic dressing for lunch, and include beets as a side for dinner.
  • Develop a daily oral care routine that excludes products with harsh antiseptics and instead uses natural alternatives like baking soda toothpaste or herbal mouth rinses. This can help maintain a healthy oral microbiome. For instance, you might brush with a baking soda-based toothpaste in the morning and evening, and rinse with a mouthwash made from diluted essential oils like peppermint or tea tree oil.
  • Incorporate a combination of outdoor activiti ...

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The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!

Strategies to Optimize Nitric Oxide Levels

Optimizing nitric oxide levels is crucial for health, and several strategies, including dietary and lifestyle adjustments, can aid in enhancing its production in the body.

Eliminate Nitric Oxide Inhibitors: Sugar, Mouthwash, Antacids

Avoid Sugary Processed Foods and Use Fluoride-Free Oral Products to Restore Nitric Oxide Production

Nathan Bryan indicates that certain products such as toothpaste and mouthwash can kill the oral microbiome, which is responsible for the production of nitric oxide. He advises against the use of mouthwash, especially following the consumption of nitric oxide-rich foods like beets, as the interaction with mouthwash or fluoridated water can inhibit the benefits. Bryan also touches on the widespread use of antacid medication and how it adversely affects the stomach's health and nutrient absorption, which in turn can indirectly affect nitric oxide levels. Furthermore, Steven Bartlett and Nathan Bryan agree on the detrimental effects of sugar on health, and Bryan emphasizes the necessity of eliminating sugar and carbohydrates from the diet to optimize nitric oxide levels.

Boosting Nitric Oxide Through Nasal Breathing, Humming, and Nitrates

Techniques to Boost Nitric Oxide Levels: Breathing Patterns and Light Wavelengths Stimulate Nitric Oxide Synthase

Nasal breathing is highlighted as a practice that activates the enzyme responsible for nitric oxide production in the sinus epithelial cells, which greatly improves oxygen uptake and transport. Additionally, humming is pinpointed as a specific action that can stimulate the nitric oxide synthase enzyme, contingent on the volume of the nasal sinuses. Certain frequencies of vibration through humming can trigger the release of nitric oxide during exhalation. Yet, Bryan warns that these techniques will be ineffective if the enzyme that produces nitric oxide isn't functioning properly.

Nitric Oxide Supplements May Aid Those Unable to Boost Levels Through Life ...

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Strategies to Optimize Nitric Oxide Levels

Additional Materials

Counterarguments

  • While Nathan Bryan suggests avoiding mouthwash to preserve the oral microbiome, some dental health professionals argue that mouthwash can be beneficial for oral hygiene and preventing disease, and that its use can be balanced with nitric oxide production.
  • The recommendation to eliminate sugar and carbohydrates entirely may be too restrictive and not suitable for everyone; a balanced diet that includes complex carbohydrates can be part of a healthy lifestyle.
  • The role of antacids in affecting nitric oxide levels may not be significant for all individuals, and antacids can be necessary for those with certain gastrointestinal conditions.
  • The effectiveness of nasal breathing and humming to significantly boost nitric oxide levels may vary among individuals and may not be as pronounced as suggested.
  • Nitric oxide supplements might not be necessary for everyone, and it's important to consider the potential for natural dietary sources of nitrates, such as vegetables, to boost nitric oxide levels.
  • The safety and efficacy of nitric oxide supplements can vary, and more research may be needed to fully understand their long-term effects an ...

Actionables

  • You can enhance your nitric oxide production by incorporating a simple humming routine during your daily activities, such as while cooking or showering, to stimulate the release of nitric oxide naturally.
    • Humming creates vibrations that can increase nitric oxide production in the sinuses. Try humming your favorite tunes or simple scales for a few minutes several times a day, especially when you're alone and it won't disturb others, like during household chores or while driving.
  • Experiment with different breathing techniques, such as diaphragmatic breathing, to encourage nasal breathing and potentially boost nitric oxide levels.
    • Diaphragmatic breathing involves deep breaths that engage the diaphragm, allowing for full oxygen exchange and promoting nasal breathing. Practice this by placing one hand on your chest and the other on your belly, ensuring that the hand on your belly rises higher than the one on your chest as you breathe in through your nose.
  • Create a personalized ...

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