Vonda Wright, a physician, joins Steven Bartlett on The Diary Of A CEO podcast to discuss the importance of bone and muscle health for longevity and disease prevention. Wright emphasizes the role of exercise, nutrition, and hormonal balance in maintaining strong bones and preventing osteoporosis, a condition linked to cognitive decline and Alzheimer's disease.
The episode explores how muscle acts as a hormone-releasing organ, supporting brain and bone health through proteins like Clotho and Irisin. Wright also delves into the physical and cognitive changes of menopause and offers strategies for managing symptoms through exercise, nutrition, and hormone therapy. Listeners will gain insights into optimizing performance through personalized approaches to diet, exercise, and lifestyle modifications.
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Vonda Wright highlights bone health's importance, emphasizing osteoporosis' prevalence and severity. At least 50% of women and 30% of men face increased fracture risk, often leading to disability or death. Wright advises maintaining bone density through exercise, nutrition with vitamins and minerals, and hormone balance.
Wright stresses the role of high-impact sports like gymnastics in building robust bones during youth when bone growth is crucial. Older master athletes demonstrate how lifelong exercise preserves bone density into the 80s.
Wright notes breastfeeding can temporarily reduce bone density by 20%, requiring 500mg calcium daily from food or supplements. Rapid postpartum weight loss should be avoided to allow bone rebuilding.
Wright highlights a link between osteoporosis and Alzheimer's, underscoring bone health's significance for cognitive function too.
Wright discusses muscle as a hormone-releasing organ regulating glucose, promoting brain and bone health, and enhancing longevity. With exercise, even older adults can build muscle to combat frailty.
During contraction, muscle releases proteins like Clotho, linked to longevity and organ repair, and Irisin, supporting bone health. Wright cites higher Clotho levels in older athletes compared to sedentary youth.
Vonda Wright recommends resistance training, with specific regimens for men and women, to counter muscle loss from declining hormones. Adequate protein, creatine, and a progressive lifting approach build and retain muscle.
Wright explains menopause's multifaceted effects, like increased bone loss, joint pain, frozen shoulder risk, and brain changes raising Alzheimer's risk. Preventive measures like exercise, nutrition, and hormone therapy can manage symptoms.
Personalized nutrition plans guided by glucose monitoring and body composition analysis optimize health and cognition, say Wright and Steven Bartlett. High-intensity exercise challenges the cardiovascular and musculoskeletal systems. Movement like standing desks and walking meetings combats sedentary lifestyles.
1-Page Summary
Vonda Wright emphasizes bone health as a crucial aspect of overall wellbeing, noting its enduring nature through history and its structural impact on appearance.
Wright discusses the prevalence of osteoporosis, a condition of low bone density, highlighting the severity of its consequences.
At least 50% of women and two million men in the United States will get osteoporosis. Wright warns that osteoporosis increases the risk of fractures, with a 50% chance of not returning to pre-fall function and a 30% risk of death if one breaks their hip. Women tend to lose bone density quickly after the age of 40, particularly during the critical decade before menopause. Osteoporosis leads to 70% of hip fractures and often results in nursing home residency due to loss of mobility. Osteoporosis is typically measured using a DEXA scan to compare an individual's bone density to that of a 30-year-old healthy person, where a T-score of minus 2.5 indicates a 40% increase in fracture risk. Wright urges that osteoporosis is preventable if proactive measures are taken early enough and stresses that a family history of shrunk height among parents could be a sign of it.
Factors contributing to bone fragility include aging, a lack of bone building during youth, sedentary lifestyles, and the misconception that women should be very thin. Wright suggests adopting an "unbreakable" lifestyle focusing on muscle, bone, nutrition, and mindset. She highlights the importance of Vitamin D and minerals such as magnesium, strontium, zinc, and boron for bone health.
Impact sports like basketball, running, and volleyball are critical for maintaining bone density. A study of masters athletes aged 40 and over showed chronic exercise helps maintain bone density into the 80s. Orthopedic researchers identified gymnastics as the most beneficial women's sport for building robust bones, due to impact and feeding of the athletes. Wright expresses concern about insufficient bone densi ...
Bone Health and Preventing Osteoporosis
Muscle strength plays a crucial role in regulating important body functions, offering protection against aging and diseases. Vonda Wright and studies on longevity and muscle function shed light on the multi-faceted benefits of muscular health.
Muscle acts as more than just a facilitator of movement; it's a metabolic endocrine organ that releases proteins during contraction which communicate with various organs, promoting longevity and overall health. Muscle acts as a sink for glucose, helping to prevent [restricted term] resistance.
For instance, skeletal muscle contraction promotes the transcription of a protein known as Clotho, associated with longevity. The presence of Clotho impacts the longevity and repair of organs, while its absence in mice leads to premature aging and death. Studies have found that older athletes have higher circulating levels of Clotho compared to young sedentary individuals, highlighting the role of muscle contraction in promoting longevity.
Other proteins like Galanin and Irisin, released during muscle contraction, respectively contribute to brain health by impacting resilience and problem-solving abilities and support bone health by aiding in the conversion of white fat into thermogenically superior brown fat.
With the body's ability to respond to strategic stress, Wright emphasizes that it's never too late to build muscle strength. Even older adults can reverse frailty by engaging in resistance training. Initiatives where sedentary participants, through consistent exercise like powerlifting, progressed to complete endurance events and core exercises showcase the potential for muscle growth at any stage of life.
Vonda Wright recommends resistance training as crucial for individuals in midlife, with specific exercise prescriptions differing for men and women based on their physiological requirements. Men are advised to lift heavier weights for eight reps and four sets, and women, post-resistance training, to lift even heavier weights for four reps and four sets. This approach counters the drop in anabolic stimulus from decreasing hormonal levels and maintains muscle mass.
The supplementation of high-quality protein, especially containing the amino acid leucine, is essential for building muscle. Wright also identifies other components, such as creatine, which benefit various bodily aspects, including muscle, brain, and bone health. This promotes muscle building for both preventative health measures and for re ...
Importance of Muscle Strength on Longevity
Vonda Wright discusses the multifaceted impact of menopause on women's health, including the decline of bone and brain health, and outlines strategies to manage its effects.
Wright acknowledges that menopause is linked to a decrease in bone density due to the dramatic drop in estrogen levels, which is critical for muscle, tendon, ligament, and bone health. As women lose estrogen, which is important for bone health, they start to lose bone density faster than men, increasing the risk of osteoporosis.
She also discusses symptoms such as arthralgia, inflammation, and limited movement, as well as an increase in musculoskeletal complaints like frozen shoulder, especially during perimenopause when estrogen levels become erratic and eventually drop significantly. Wright describes how tissues such as muscle, bone, tendon, and ligament are sensitive to estrogen and function less effectively without it due to the presence of estrogen receptors.
Wright emphasizes that hormone replacement decisions should be based on science. She encourages preventive measures and lifestyle changes, such as engaging in weight training, cardio exercises, and anti-inflammatory nutrition.
Moreover, she introduced the term "Musculoskeletal Syndrome of Menopause" to help doctors recognize the interconnected symptoms without going through a long differential diagnosis. Wright believes that hormone replacement therapy can help prevent the musculoskeletal syndrome of menopause and manage pain when receptors sitting empty during menopause cause symptoms.
Wright stresses not only the importance of bone health but also preserving brain function during meno ...
Physical and Cognitive Changes of Menopause and Management
Wright and Bartlett emphasize the importance of diet, exercise, and lifestyle adjustments for enhancing physical and cognitive function.
The integration of precision health practices into diet and exercise regimes can significantly augment personal wellbeing and cognitive function.
Wright acknowledges the relevance of glucose monitoring and body composition analysis in personal health optimization. For instance, continuous glucose monitors (CGMs) are instrumental in recording how stress or exercise affects blood sugar levels. She advocates the use of these tools to inform individuals about the internal functions of their bodies.
Steven Bartlett discusses Zoe, a company that offers advanced at-home gut health tests, including a blood sugar sensor and a blood sample analysis for a customized nutrition plan. Similarly, Wright uses lactate threshold testing to ascertain the transition point of mitochondria from fat to carbohydrate burning, denoting the most efficient state, and evidences the importance of exercising at this intensity for optimal cardiovascular and musculoskeletal system function.
Intense physical activities such as resistance training and sprint intervals are key in challenging the body's musculoskeletal and cardiovascular systems, which are e ...
Maintaining Physical and Cognitive Performance: Diet, Exercise, and Lifestyle Factors
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