Podcasts > The Diary Of A CEO with Steven Bartlett > The Ageing Doctor: These Are They Early Signs Of Arthritis! If You Run & Don't Do This, Start Now! The Secret Cause of Alzheimer's!

The Ageing Doctor: These Are They Early Signs Of Arthritis! If You Run & Don't Do This, Start Now! The Secret Cause of Alzheimer's!

By Steven Bartlett

Vonda Wright, a physician, joins Steven Bartlett on The Diary Of A CEO podcast to discuss the importance of bone and muscle health for longevity and disease prevention. Wright emphasizes the role of exercise, nutrition, and hormonal balance in maintaining strong bones and preventing osteoporosis, a condition linked to cognitive decline and Alzheimer's disease.

The episode explores how muscle acts as a hormone-releasing organ, supporting brain and bone health through proteins like Clotho and Irisin. Wright also delves into the physical and cognitive changes of menopause and offers strategies for managing symptoms through exercise, nutrition, and hormone therapy. Listeners will gain insights into optimizing performance through personalized approaches to diet, exercise, and lifestyle modifications.

The Ageing Doctor: These Are They Early Signs Of Arthritis! If You Run & Don't Do This, Start Now! The Secret Cause of Alzheimer's!

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The Ageing Doctor: These Are They Early Signs Of Arthritis! If You Run & Don't Do This, Start Now! The Secret Cause of Alzheimer's!

1-Page Summary

Bone Health and Preventing Osteoporosis

Vonda Wright highlights bone health's importance, emphasizing osteoporosis' prevalence and severity. At least 50% of women and 30% of men face increased fracture risk, often leading to disability or death. Wright advises maintaining bone density through exercise, nutrition with vitamins and minerals, and hormone balance.

Impact Sports Build Strong Bones In Youth

Wright stresses the role of high-impact sports like gymnastics in building robust bones during youth when bone growth is crucial. Older master athletes demonstrate how lifelong exercise preserves bone density into the 80s.

Breastfeeding and Adequate Calcium Intake

Wright notes breastfeeding can temporarily reduce bone density by 20%, requiring 500mg calcium daily from food or supplements. Rapid postpartum weight loss should be avoided to allow bone rebuilding.

Osteoporosis Linked To Cognitive Decline

Wright highlights a link between osteoporosis and Alzheimer's, underscoring bone health's significance for cognitive function too.

Importance of Muscle Strength on Longevity

Wright discusses muscle as a hormone-releasing organ regulating glucose, promoting brain and bone health, and enhancing longevity. With exercise, even older adults can build muscle to combat frailty.

Muscle Contraction Releases Anti-Aging Proteins

During contraction, muscle releases proteins like Clotho, linked to longevity and organ repair, and Irisin, supporting bone health. Wright cites higher Clotho levels in older athletes compared to sedentary youth.

Resistance Training Maintains Muscle Mass

Vonda Wright recommends resistance training, with specific regimens for men and women, to counter muscle loss from declining hormones. Adequate protein, creatine, and a progressive lifting approach build and retain muscle.

Physical and Cognitive Changes of Menopause

Wright explains menopause's multifaceted effects, like increased bone loss, joint pain, frozen shoulder risk, and brain changes raising Alzheimer's risk. Preventive measures like exercise, nutrition, and hormone therapy can manage symptoms.

Maintaining Performance: Diet, Exercise, Lifestyle

Personalized nutrition plans guided by glucose monitoring and body composition analysis optimize health and cognition, say Wright and Steven Bartlett. High-intensity exercise challenges the cardiovascular and musculoskeletal systems. Movement like standing desks and walking meetings combats sedentary lifestyles.

1-Page Summary

Additional Materials

Counterarguments

  • While impact sports can build strong bones in youth, not all individuals may be able to participate in high-impact sports due to various reasons such as disabilities, chronic conditions, or personal preferences. Alternative low-impact exercises that can also contribute to bone health should be considered.
  • The recommendation for breastfeeding women to increase calcium intake might not account for individual variations in calcium absorption and metabolism. Some women may require more or less than the suggested 500mg of additional calcium.
  • The link between osteoporosis and cognitive decline, including Alzheimer's, is an area of ongoing research, and it is important to note that correlation does not necessarily imply causation. Other factors may contribute to both conditions.
  • The emphasis on muscle strength for longevity may overlook other factors that contribute to a long and healthy life, such as genetics, mental health, and social connections.
  • The suggestion that muscle contraction releases anti-aging proteins may be an oversimplification of the complex biological processes involved in aging, and the role of these proteins in longevity is still being explored.
  • Resistance training recommendations may not be suitable for everyone, and individual health conditions should be taken into account. Some people may benefit more from other types of exercise due to their specific health concerns or limitations.
  • The focus on hormone therapy as a preventive measure for menopausal symptoms does not consider the potential risks and side effects associated with such treatments, which may outweigh the benefits for some women.
  • Personalized nutrition plans and glucose monitoring may not be accessible or affordable for everyone, potentially limiting their applicability across different socioeconomic groups.
  • The advice to combat sedentary lifestyles with standing desks and walking meetings may not be practical for all work environments or for individuals with certain physical disabilities.

Actionables

  • You can integrate balance exercises like standing on one leg while brushing your teeth to improve bone density and stability. This simple addition to your daily routine engages your muscles and bones without requiring extra time out of your day, and it can be especially beneficial as you age to maintain balance and prevent falls.
  • Create a "bone-healthy" recipe swap club with friends or family to encourage diverse nutrient intake for bone health. Each member can contribute a recipe that's rich in calcium, vitamin D, and other bone-supporting nutrients once a month, which not only makes meal planning easier but also introduces you to new foods that contribute to bone health.
  • Use a step counter app to set incremental weekly goals that increase your daily steps, aiming to incorporate more walking into your routine. Start with a manageable increase from your current average, such as adding 500 steps per week, to gradually build up to a more active lifestyle that supports bone and muscle health.

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The Ageing Doctor: These Are They Early Signs Of Arthritis! If You Run & Don't Do This, Start Now! The Secret Cause of Alzheimer's!

Bone Health and Preventing Osteoporosis

Vonda Wright emphasizes bone health as a crucial aspect of overall wellbeing, noting its enduring nature through history and its structural impact on appearance.

Osteoporosis: 50% of Women, 30% of Men Face Fracture Risk, Leading To Disability or Death

Wright discusses the prevalence of osteoporosis, a condition of low bone density, highlighting the severity of its consequences.

Maintaining Bone Density: Exercise, Nutrition, and Hormone Balance

At least 50% of women and two million men in the United States will get osteoporosis. Wright warns that osteoporosis increases the risk of fractures, with a 50% chance of not returning to pre-fall function and a 30% risk of death if one breaks their hip. Women tend to lose bone density quickly after the age of 40, particularly during the critical decade before menopause. Osteoporosis leads to 70% of hip fractures and often results in nursing home residency due to loss of mobility. Osteoporosis is typically measured using a DEXA scan to compare an individual's bone density to that of a 30-year-old healthy person, where a T-score of minus 2.5 indicates a 40% increase in fracture risk. Wright urges that osteoporosis is preventable if proactive measures are taken early enough and stresses that a family history of shrunk height among parents could be a sign of it.

Factors contributing to bone fragility include aging, a lack of bone building during youth, sedentary lifestyles, and the misconception that women should be very thin. Wright suggests adopting an "unbreakable" lifestyle focusing on muscle, bone, nutrition, and mindset. She highlights the importance of Vitamin D and minerals such as magnesium, strontium, zinc, and boron for bone health.

Impact Sports Build Strong Bones In Youth

Impact sports like basketball, running, and volleyball are critical for maintaining bone density. A study of masters athletes aged 40 and over showed chronic exercise helps maintain bone density into the 80s. Orthopedic researchers identified gymnastics as the most beneficial women's sport for building robust bones, due to impact and feeding of the athletes. Wright expresses concern about insufficient bone densi ...

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Bone Health and Preventing Osteoporosis

Additional Materials

Clarifications

  • A DEXA scan is a type of bone density test that uses low-dose X-rays to measure the mineral content and density of bones. The T-score compares an individual's bone density to that of a healthy young adult of the same sex and ethnicity, typically a 30-year-old. A T-score of -2.5 or lower indicates low bone density, which increases the risk of fractures. The T-score helps healthcare providers assess the risk of osteoporosis and fracture in an individual.
  • The connection between Alzheimer's disease and osteoporosis lies in research suggesting a potential link between the two conditions. Studies have shown that individuals with Alzheimer's disease may also have a higher prevalence of osteoporosis. This association highlights the importance of bone health not only for physical well-being but also for cognitive function. Further research is needed to fully understand the underlyi ...

Counterarguments

  • While exercise and nutrition are important for maintaining bone density, genetic factors also play a significant role in an individual's risk for osteoporosis, which may not be entirely preventable for everyone.
  • The statement that 50% of women and 30% of men will face a fracture risk due to osteoporosis might not account for regional, ethnic, or socioeconomic variations that can influence these statistics.
  • The emphasis on impact sports for building bone density in youth may overlook other forms of physical activity that can also be beneficial, such as swimming or cycling, which are low-impact but can still contribute to overall health.
  • The recommendation for a specific intake of calcium during breastfeeding does not consider individual dietary requirements or potential medical conditions that might affect calcium absorption or metabolism.
  • The link between osteoporosis and cognitive decline, specifically Alzheimer's disease, may not imply causation, and more research might be needed to understand the nature of this correlation fully.
  • The focus on an "u ...

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The Ageing Doctor: These Are They Early Signs Of Arthritis! If You Run & Don't Do This, Start Now! The Secret Cause of Alzheimer's!

Importance of Muscle Strength on Longevity

Muscle strength plays a crucial role in regulating important body functions, offering protection against aging and diseases. Vonda Wright and studies on longevity and muscle function shed light on the multi-faceted benefits of muscular health.

Muscle Is a Hormone-Releasing Organ Key to Glucose Regulation, Brain Health, and Longevity

Muscle acts as more than just a facilitator of movement; it's a metabolic endocrine organ that releases proteins during contraction which communicate with various organs, promoting longevity and overall health. Muscle acts as a sink for glucose, helping to prevent [restricted term] resistance.

For instance, skeletal muscle contraction promotes the transcription of a protein known as Clotho, associated with longevity. The presence of Clotho impacts the longevity and repair of organs, while its absence in mice leads to premature aging and death. Studies have found that older athletes have higher circulating levels of Clotho compared to young sedentary individuals, highlighting the role of muscle contraction in promoting longevity.

Other proteins like Galanin and Irisin, released during muscle contraction, respectively contribute to brain health by impacting resilience and problem-solving abilities and support bone health by aiding in the conversion of white fat into thermogenically superior brown fat.

Maintaining Muscle Mass as We Age Through Resistance Training

With the body's ability to respond to strategic stress, Wright emphasizes that it's never too late to build muscle strength. Even older adults can reverse frailty by engaging in resistance training. Initiatives where sedentary participants, through consistent exercise like powerlifting, progressed to complete endurance events and core exercises showcase the potential for muscle growth at any stage of life.

Vonda Wright recommends resistance training as crucial for individuals in midlife, with specific exercise prescriptions differing for men and women based on their physiological requirements. Men are advised to lift heavier weights for eight reps and four sets, and women, post-resistance training, to lift even heavier weights for four reps and four sets. This approach counters the drop in anabolic stimulus from decreasing hormonal levels and maintains muscle mass.

The supplementation of high-quality protein, especially containing the amino acid leucine, is essential for building muscle. Wright also identifies other components, such as creatine, which benefit various bodily aspects, including muscle, brain, and bone health. This promotes muscle building for both preventative health measures and for re ...

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Importance of Muscle Strength on Longevity

Additional Materials

Clarifications

  • Clotho is a protein associated with longevity and organ repair. Galanin impacts brain health by enhancing resilience and problem-solving abilities. Irisin contributes to bone health by converting white fat into brown fat, which is more metabolically active. These proteins are released during muscle contraction and play essential roles in promoting overall health and well-being.
  • In the context of resistance training, men are typically advised to lift heavier weights for eight reps and four sets to cater to their physiological needs for muscle growth. On the other hand, women are recommended to lift even heavier weights for four reps and four sets post-resistance training to stimulate muscle development effectively. These differing exercise prescriptions aim to optimize muscle building outcomes based on the biological differences between men and women. The variations in resistance training approaches for men and women help address their unique muscle-building requirements and hormonal responses to exercise.
  • Leucine is an essential amino acid found in high-quality proteins that plays a crucial role in stimulating muscle protein synthesis, which is the process of building new muscle tissue. It is considered a key trigger for muscle growth and repair, especially when consumed in adequate amounts post-exercise. Leucine-rich foods like meat, poultry, fish, dairy products, and legumes are beneficial for individuals looking to optimize muscle building and recovery. Including leucine in the diet, particularly in combination with resistance training, can help enhance muscle protein synthesis and support overall muscle health.
  • Creatine is a naturally occurring compound that plays a vital role in providing energy to cells, particularly during high-intensity exercise. It is known to enhance muscle strength and power, making it a popular supplement among athletes and fitness enthusiasts. Additionally, creatine has shown potential benefits for cognitive function, potentially improving brain health. Moreover, research suggests that creatine may also have positive effects on bone health, although more studies are needed to fully understand this aspect.
  • Estrogen plays a role i ...

Counterarguments

  • While muscle strength is important for longevity, genetic factors and other lifestyle choices such as diet, sleep, and stress management also play significant roles in aging and disease prevention.
  • The endocrine function of muscle is just one aspect of metabolic health, and other organs like the liver and pancreas are also critical in glucose regulation.
  • The relationship between muscle contraction and the release of proteins like Clotho is complex, and more research may be needed to fully understand the mechanisms and their impact on longevity.
  • The benefits of resistance training for older adults are clear, but individual health conditions and physical limitations must be considered, and some may require tailored or supervised exercise programs.
  • The specific exercise prescriptions for men and women mentioned in the text may not account for individual variability and preferences, and a one-size-fits-all approach may not be optimal.
  • While protein and supplements like creatine can support muscle building, they should be used judiciously, and the importance of a balanced diet with adequate nutrients should not be overlooked.
  • Resistance training's role in disease prevention is supported by evidence, but it is not a panacea; a multifaceted approach to health is necessary to prevent diseases like di ...

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The Ageing Doctor: These Are They Early Signs Of Arthritis! If You Run & Don't Do This, Start Now! The Secret Cause of Alzheimer's!

Physical and Cognitive Changes of Menopause and Management

Vonda Wright discusses the multifaceted impact of menopause on women's health, including the decline of bone and brain health, and outlines strategies to manage its effects.

Menopause Can Cause Joint Pain, Frozen Shoulder, Tendinitis, and Osteoporosis

Wright acknowledges that menopause is linked to a decrease in bone density due to the dramatic drop in estrogen levels, which is critical for muscle, tendon, ligament, and bone health. As women lose estrogen, which is important for bone health, they start to lose bone density faster than men, increasing the risk of osteoporosis.

She also discusses symptoms such as arthralgia, inflammation, and limited movement, as well as an increase in musculoskeletal complaints like frozen shoulder, especially during perimenopause when estrogen levels become erratic and eventually drop significantly. Wright describes how tissues such as muscle, bone, tendon, and ligament are sensitive to estrogen and function less effectively without it due to the presence of estrogen receptors.

"Menopausal Musculoskeletal Syndrome: Manageable With Hormone Therapy and Lifestyle Changes"

Wright emphasizes that hormone replacement decisions should be based on science. She encourages preventive measures and lifestyle changes, such as engaging in weight training, cardio exercises, and anti-inflammatory nutrition.

Moreover, she introduced the term "Musculoskeletal Syndrome of Menopause" to help doctors recognize the interconnected symptoms without going through a long differential diagnosis. Wright believes that hormone replacement therapy can help prevent the musculoskeletal syndrome of menopause and manage pain when receptors sitting empty during menopause cause symptoms.

Wright stresses not only the importance of bone health but also preserving brain function during meno ...

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Physical and Cognitive Changes of Menopause and Management

Additional Materials

Clarifications

  • Menopausal Musculoskeletal Syndrome is a term used to describe a cluster of musculoskeletal symptoms that can occur during menopause, such as joint pain, frozen shoulder, and tendinitis. These symptoms are believed to be influenced by the hormonal changes, particularly the decrease in estrogen levels, that women experience during menopause. Hormone replacement therapy and lifestyle changes like exercise and nutrition are suggested as management strategies for this syndrome.
  • A differential diagnosis is a method used in healthcare to distinguish between different diseases or conditions that share similar symptoms. Clinicians use this approach to identify the specific illness affecting a patient or to rule out life-threatening conditions. It involves considering various possible diseases based on symptoms, patient history, and medical knowledge to arrive at an accurate diagnosis. Differential diagnosis helps healthcare providers make informed decisions by systematically evaluating and eliminating potential conditions until the most probable diagnosis is reached.
  • [restricted term] insensitivity, also known as [restricted term] resistance, is a condition where cells do not respond effectively to [restricted term], leading to difficulties in regulating blood sugar levels. This can occur due to various factors like obesity, sedentary lifestyle, genetics, and certain health conditions. Lifestyle changes such as weight management, exercise, and dietary adjustments can help improve [restricted term] sensitivity and manage blood sugar levels.
  • Prediabetes is a condition where blood sugar levels are higher than normal but not high enough to be classified as diabetes. It often precedes the development of type 2 diabetes and is associated with risk factors like obesity, high blood pressure, and abnormal cholesterol levels. Lifestyle changes such as exercise and dietary adjustments are key in managing prediabetes and reducing the risk of progression to diabetes. Prediabetes can be reversible with early intervention and healthy habits ...

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The Ageing Doctor: These Are They Early Signs Of Arthritis! If You Run & Don't Do This, Start Now! The Secret Cause of Alzheimer's!

Maintaining Physical and Cognitive Performance: Diet, Exercise, and Lifestyle Factors

Wright and Bartlett emphasize the importance of diet, exercise, and lifestyle adjustments for enhancing physical and cognitive function.

Optimizing Health and Performance With Personalized Nutrition

The integration of precision health practices into diet and exercise regimes can significantly augment personal wellbeing and cognitive function.

Tools For Glucose Monitoring and Body Composition Analysis Guide Nutritional and Exercise Plans

Wright acknowledges the relevance of glucose monitoring and body composition analysis in personal health optimization. For instance, continuous glucose monitors (CGMs) are instrumental in recording how stress or exercise affects blood sugar levels. She advocates the use of these tools to inform individuals about the internal functions of their bodies.

Steven Bartlett discusses Zoe, a company that offers advanced at-home gut health tests, including a blood sugar sensor and a blood sample analysis for a customized nutrition plan. Similarly, Wright uses lactate threshold testing to ascertain the transition point of mitochondria from fat to carbohydrate burning, denoting the most efficient state, and evidences the importance of exercising at this intensity for optimal cardiovascular and musculoskeletal system function.

High-Intensity Exercise Challenges Cardiovascular, Musculoskeletal Systems to Maintain Function

Intense physical activities such as resistance training and sprint intervals are key in challenging the body's musculoskeletal and cardiovascular systems, which are e ...

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Maintaining Physical and Cognitive Performance: Diet, Exercise, and Lifestyle Factors

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Counterarguments

  • While precision health practices can be beneficial, they may not be accessible or affordable for everyone, potentially creating disparities in health optimization opportunities.
  • Continuous glucose monitoring might be unnecessary for individuals without diabetes or other specific health conditions, and over-monitoring can lead to unnecessary stress or obsession over data.
  • Advanced at-home gut health tests like those offered by Zoe could provide valuable insights, but the science of gut health and its impact on overall wellbeing is still emerging and may not be conclusive for all individuals.
  • Lactate threshold testing can be a useful tool for athletes, but its relevance for the general population may be limited, as not everyone requires such detailed physiological metrics to improve their health or fitness.
  • High-intensity exercises are beneficial but may not be suitable for everyone, especially those with certain health conditions, injuries, or a lower level of fitness.
  • Resistance training and sprint intervals are important, but they should be balanced with other forms of exercise to ...

Actionables

  • You can enhance your cognitive function by pairing brain-training apps with your exercise routine. While you're on a treadmill or stationary bike, use apps designed to improve memory, problem-solving, or language skills. This dual-tasking approach can make your workouts more mentally engaging and potentially boost both cognitive and physical performance.
  • Create a personalized mini-challenge each week to integrate new healthy habits into your lifestyle. For instance, if you usually take the elevator, challenge yourself to use the stairs every day for a week. The next week, you might add a new vegetable to your meals or replace a sugary snack with a healthier option. These small, incremental changes can lead to significant improvements in your overall wellbeing without feeling overwhelming.
  • Organize a "walk and talk" book club wi ...

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