In this episode of the Huberman Lab, Huberman examines cortisol's role beyond its reputation as just a stress hormone, explaining how it helps deliver energy to tissues throughout the body and follows a natural 24-hour rhythm. He describes the biological mechanisms controlling cortisol production and details how cortisol levels influence our daily energy patterns.
The episode covers practical approaches to managing cortisol levels, from morning sunlight exposure and strategic caffeine timing to evening relaxation techniques and dietary adjustments. Huberman explores the connection between cortisol irregularities and burnout, presenting two common patterns of cortisol dysfunction. He outlines strategies for addressing these patterns through lifestyle modifications and explains the potential role of supplements in supporting cortisol regulation.
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Andrew Huberman explains that while cortisol is commonly known as a stress hormone, it serves a broader purpose in mobilizing glucose and fuels to tissues requiring energy. As a cholesterol-derived hormone, cortisol follows a distinct 24-hour rhythm, peaking in the morning and gradually declining throughout the day.
The hormone's production is regulated through the Hypothalamic-Pituitary-Adrenal (HPA) axis, involving a complex feedback system. When cortisol levels are low, CRH stimulates ACTH release, which then signals the adrenal glands to produce cortisol. As levels rise, a negative feedback loop prevents overproduction.
To enhance morning cortisol levels, Huberman recommends getting sunlight exposure within the first hour of waking, staying hydrated, and exercising in the morning or early afternoon. He suggests delaying caffeine intake by 60-90 minutes after waking to maintain steady cortisol levels throughout the day.
For evening cortisol reduction, Huberman advises dimming lights, avoiding screens, and practicing relaxation techniques like the 'physiological sigh.' He notes that consuming starchy carbohydrates in evening meals can help lower cortisol levels. Supplements like Ashwagandha (300-600mg) and Apigenin (50mg) may modestly reduce cortisol when taken in the evening.
Huberman identifies two main patterns of cortisol dysregulation in burnout: one characterized by high morning cortisol followed by afternoon crashes, and another marked by morning sluggishness with evening alertness. To address these patterns, he recommends using non-sleep deep rest (NSDR) or yoga nidra after waking, prioritizing good sleep hygiene, and implementing stress-reduction practices. While supplements can help, Huberman emphasizes that they should not replace fundamental lifestyle changes in managing cortisol levels and preventing burnout.
1-Page Summary
Cortisol is often associated with stress, but as Andrew Huberman explains, it's a hormone crucial for mobilizing glucose and fuels to tissues that need the most energy.
Cortisol is a corticosteroid hormone that plays a key role in the deployment and direction of energy, particularly glucose, to specific tissues such as the brain for dealing with energy demands that go beyond stress responses. This hormone, which is derived from cholesterol, is also essential for brain function, focus, and the process of waking up in the morning.
Cortisol exhibits a 24-hour rhythm with four distinct phases. The hormone’s levels are lowest during the initial hours of sleep, with minimal secretory activity. During sleep, cortisol begins to rise slightly and then increases rapidly during the sixth to eighth hours, coinciding with REM sleep—a time of robust brain activity which requires energy sourced from blood glucose. Upon waking, cortisol experiences a secretory activity surge, peaking in the late morning or around noon and then gradually declining throughout the day. Andrew Huberman emphasizes the importance of high morning cortisol levels for energy, alertness, and mood, noting that cortisol should spike in the morning and decrease steadily as the evening approaches.
Cortisol’s circadian rhythm and its regulation are part of the feedback system within the Hypothalamic-Pituitary-Adrenal (HPA) axis.
The neurons that release CRH ([restricted term]-releasing hormone) monitor the levels of cortisol in the bloodstream.
When cortisol levels ...
The Biology and Circadian Rhythm of Cortisol
Cortisol, a critical hormone in the body, has varying levels throughout the day, and learning how to optimize these levels can lead to improved health, wellness, and performance.
To enhance morning cortisol levels for increased energy and alertness, consider the following methods:
Andrew Huberman highlights the importance of getting sunlight into your eyes within the first hour of waking, ideally within the first 30 minutes. This exposure boosts cortisol levels significantly, which is especially important on overcast days. When sunlight isn't available, a 10,000 lux artificial light can act as a substitute until you can access natural light. Bright light exposure early in the day not only enhances mood, focus, and alertness but also sets the stage for low cortisol levels in the evening, aiding sleep.
Hydration is crucial after waking up, as it can enhance alertness, energy, and lead to a modest increase in cortisol. Drinking 16 to 32 ounces of water, with or without electrolytes, can significantly help. Caffeine may also spike cortisol, particularly in people who are not chronic caffeine users. Even if cortisol levels do not markedly rise for those adapted to caffeine, it can prolong cortisol's effectiveness. However, to avoid a sharp drop in cortisol levels later in the day, Andrew Huberman suggests delaying caffeine intake by 60 to 90 minutes after waking.
Regular exercise, especially if performed early in the day, can increase cortisol. While familiar routines may not cause a dramatic rise, they act as a cue for the body's circadian clock. Such exercises should ideally be done in the same two to three-hour window each day for consistency. Evening exercise might increase cortisol levels, but if done early enough, it shouldn't disrupt the natural decline in this hormone.
In the evening, to foster better sleep, it's essential to lower cortisol levels through several methods:
Cutting off bright artificial light and short-wavelength light from screens can keep cortisol levels low. Dimming indoor lights, especially two hours after sunset, can be beneficial. Red or amber lighting from incandescent bulbs are good choices to support relaxation. Implementing phone settings or glasses that filter out short-wavelength light may also be helpful in managing cortisol.
Methods such as the 'physiological sigh,' composed of a double inhale followed by a long exhale, can quickly decrease stress and shift the body from a sympathetic state to a p ...
Optimizing Cortisol Levels Throughout the Day
Huberman delves into the complexity of burnout, debunking the idea that it's purely about depleted adrenals and placing emphasis on the importance of cortisol rhythm management for overall health and navigating life effectively.
Burnout is deeply connected to the dysregulation of cortisol, and identifying specific patterns of cortisol levels throughout the day can indicate burnout stages and guide potential interventions.
Huberman doesn't specifically mention "Phase Burnout," but he does recognize patterns consistent with the concept. One pattern he notes is characterized by individuals waking up with extreme stress after insufficient sleep, which suggests elevated morning cortisol levels followed by a crash in the afternoon. This crash can lead to a foggy state and forgetfulness.
The second pattern of burnout is marked by morning sluggishness and lethargy, with an inability to slow down in the evening, making it difficult to calm the mind for sleep. Huberman describes this flip in energy levels, noting a pattern where individuals feel more awake in the afternoon and then experience high stress levels and trouble sleeping at night.
To effectively combat burnout, it's crucial to restore a healthy cortisol rhythm, ensuring high levels in the morning and low levels by evening to facilitate sleep and improve energy levels.
For early phase burnout, Huberman recommends using non-sleep deep rest (NSDR), also known as yoga nidra, right after waking to reduce stress and potentially promote sleep. These practices engage the parasympathetic nervous system and can be used to adjust the slope of cortisol increase.
Huberman emphasizes the importance of excellent sleep ...
The Relationship Between Cortisol Dysregulation and Burnout
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