Podcasts > Cover Up > The Anthrax Threat I 5. Mr. Anthrax

The Anthrax Threat I 5. Mr. Anthrax

By Sony Music

The Cover Up podcast dives into the chilling anthrax attacks of 2001 and the investigation's surprising connections to a United States Army biodefense lab. The episode examines the history of bioweapons research that preceded the transition to defensive study at USAMRIID. It details the complex collaboration between the lab's scientists and the FBI, leading to a breakthrough that genetically linked the anthrax used in the attacks to a specific flask from USAMRIID.

As suspicion grows around one of the lab's top anthrax experts, Bruce Ivins, the episode delves into the tensions between investigators pursuing different leads. It highlights the challenges faced in tracing such a lethal and rare pathogen to its source, raising questions about the investigation's focus on a single suspect.

The Anthrax Threat I 5. Mr. Anthrax

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The Anthrax Threat I 5. Mr. Anthrax

1-Page Summary

History of bioweapons research and USAMRIID

Following the 1969 Bioweapons Treaty signed by President Nixon, the U.S. transitioned from developing bioweapons to defensive research at USAMRIID. Despite housing dangerous pathogens, Jeff Adamovicz and Hank Heine noted USAMRIID had a surprisingly casual culture with lax security measures.

Collaboration between USAMRIID and the FBI

During the 2001 Amerithrax anthrax attacks investigation, the FBI enlisted USAMRIID microbiologists like Bruce Ivins, a top anthrax expert, for their expertise. These scientists were dedicated to assisting the FBI, though tracing anthrax sources via genetic analysis proved challenging.

The forensic breakthrough with anthrax "morphs"

An accidental discovery at USAMRIID revealed distinctive "morphs" - rare anthrax mutations that can visually link samples to their source lab. FBI sampling found only 8 samples matching the attack letters' morphs, all traced to a flask (RMR-1029) at USAMRIID.

Suspicion and investigation of Bruce Ivins

Bruce Ivins drew suspicion for unauthorized anthrax cleanup, his presence at key evidence sites, and being RMR-1029's custodian. Submitting an incorrect sample to the FBI further heightened suspicion of his involvement.

Tensions within the Amerithrax investigative team

Rick Lambert, the Amerithrax lead investigator, was unconvinced of Ivins' guilt and wanted to investigate other potential sources like Dugway and Battelle. However, FBI pressure mounted to focus solely on Ivins despite Lambert's reservations.

1-Page Summary

Additional Materials

Counterarguments

  • The transition to defensive research at USAMRIID after the 1969 Bioweapons Treaty does not necessarily mean that all offensive bioweapons research ceased; it could have been continued covertly or under different guises.
  • The characterization of USAMRIID's culture as "surprisingly casual" with "lax security measures" could be misleading without specific examples, as security protocols might have been adequate for the time and only seem lax in retrospect.
  • The involvement of USAMRIID microbiologists in the FBI investigation could be seen as a conflict of interest, especially if any of them, like Bruce Ivins, were later considered suspects.
  • The difficulty in tracing anthrax sources via genetic analysis might not solely be due to the complexity of the task but could also be attributed to limitations in the technology or methodology available at the time.
  • The discovery of distinctive "morphs" linking anthrax samples to their source lab could be questioned for its scientific reliability and the possibility of contamination or other labs having similar strains.
  • The fact that all 8 samples matching the attack letters' morphs were traced to a flask at USAMRIID does not conclusively prove the source of the anthrax, as there could have been other undiscovered or untested sources.
  • Bruce Ivins' suspicious activities could have alternative explanations unrelated to guilt, such as poor judgment or procedural mistakes.
  • The focus on Ivins by the FBI could be criticized for potentially being too narrow, possibly overlooking other leads or evidence that might have pointed to a different suspect or additional collaborators.
  • Rick Lambert's desire to investigate other potential sources could be seen as a diligent attempt to ensure a thorough investigation, rather than a sign of being unconvinced of Ivins' guilt.

Actionables

  • You can enhance your personal security protocols by conducting a self-audit of your digital and physical security measures. Review your passwords, update your antivirus software, and ensure your sensitive documents are securely stored. This mirrors the importance of stringent security in environments handling sensitive materials, as a casual approach can lead to vulnerabilities.
  • Develop a habit of detailed record-keeping for your personal projects or work tasks. By documenting processes, variations, and outcomes, you create a traceable record that can help identify the origins of any issues that arise, similar to how distinctive morphs in the anthrax samples were used to trace their source.
  • Practice critical thinking by exploring alternative explanations when faced with a problem. Instead of focusing on a single hypothesis, list out all possible scenarios and evaluate the evidence for each. This approach is akin to the investigator's desire to explore multiple sources in a complex investigation, promoting thoroughness and objectivity.

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The Anthrax Threat I 5. Mr. Anthrax

History of bioweapons research and USAMRIID

USAMRIID's evolution from bioweapons research to a defensive focus is a critical element of its history, along with concerns about the laxity of its security measures.

USAMRIID's origins as a bioweapons research facility

In 1969, the United States, following the International Bioweapons Treaty signed by President Richard Nixon, pledged to cease developing bioweapons. This commitment led to the restructuring of the Fort Detrick bioweapons program into the United States Army Medical Research Institute of Infectious Diseases (USAMRIID). The facility transitioned its focus solely to defense-oriented research, aiming to protect against potential biological threats rather than create them.

The shift to defensive research after the Bioweapons Treaty

With the signing of the treaty, USAMRIID began directing its expertise and resources toward defensive measures against infectious diseases and potential bioterrorism, reflecting a global shift in stance on the production and use of biological weapons.

Lax security at USAMRIID despite housing dangerous pathogens

Despite its critical role in biosecurity, USAMRIID had surprisingly relaxed measures in places, placing trust in the professionalism of its staff and the unspoken rule of responsibility given the nature of the work conducted there.

Scientists at USAMRIID had a close-knit, casual culture

Jeff Adamovicz and Hank Heine observed that, during their tenure, the culture among USAMRI ...

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History of bioweapons research and USAMRIID

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Clarifications

  • USAMRIID stands for the United States Army Medical Research Institute of Infectious Diseases. It evolved from a bioweapons research facility to focus on defensive research after the United States committed to ceasing bioweapons development in 1969. Despite its role in biosecurity, USAMRIID faced criticism for lax security measures, contrasting the serious nature of the pathogens it housed.
  • Fort Detrick was a key location for the U.S. biological weapons program from 1943 to 1969. After the program ended, it became a hub for the U.S. biological defense program, hosting research on pathogens like Ebola and smallpox. The facility houses the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) and other important biomedical research entities. In 2019, Fort Detrick's germ research operations were temporarily halted due to safety violations related to the disposal of hazardous materials.
  • The International Bioweapons Treaty, also known as the Biological Weapons Convention (BWC), is an international treaty that prohibits the development, production, and stockpiling of biological weapons. It was signed in 1972 and aimed to enhance global security by preventing the use of biological agents as weapons of war. The treaty promotes peaceful cooperation in the field of biology and sets guidelines for the peaceful use of biological research. Member countries commit to not using biological agents as weapons and to only engage in defensive research for public health and safety.
  • Bioterrorism involves the deliberate release of harmful biological agents, like viruses or bacteria, to cause harm or instill fear. These agents can be modified to be more dangerous or resistant to treatment. Bioterrorism is attractive to terrorists due to its potential widespread impact and difficulty in detection.
  • Pathogens are organisms or ...

Counterarguments

  • The shift from offensive to defensive research at USAMRIID may not have been as clear-cut, with some arguing that defensive research can still inform offensive capabilities.
  • The casual culture among scientists could be seen as a necessary counterbalance to the high-stress environment, potentially fostering better communication and collaboration which is crucial in high-stakes research.
  • Lax security measures might be overstated; while the culture appeared casual, there could have been unseen or unmentioned layers of security protocols and measures in place.
  • Comparing USAMRIID security to airport security might not be appropriate, as the two environments have different operational requirements and threat profiles.
  • The open gates mentioned could be part of a broader security strategy that is not immediately apparent to outsiders or even to ...

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The Anthrax Threat I 5. Mr. Anthrax

Collaboration between USAMRIID and the FBI in the Amerithrax investigation

During the Amerithrax investigation, the complex and high-stakes nature of the case necessitated a unique collaboration between the FBI and USAMRIID scientists, who provided crucial expertise.

USAMRIID scientists lent their expertise to the Amerithrax investigation

In 2002, the FBI's Amerithrax squad, led by John Kerr, recognized that the expertise needed for the investigation exceeded what the FBI laboratory could provide. The murder weapon was a rare and dangerous bacteria, anthrax, which required specialized knowledge and facilities to study. The FBI turned to a group of renowned microbiologists with federal security clearance to assist in the case.

The microbiologists were dedicated to helping crack the case

These scientists, from the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), had been helping with the Amerithrax investigation almost from the outset. Among them was Bruce Ivins, one of the leading anthrax experts in the world. Ivins was tasked with evaluating the anthrax spores found in a letter addressed to then-Senator Tom Daschle the day after it arrived at USAMRIID.

Ivins and his colleagues from the microbiology department at USAMRIID demonstrated deep commitment to assisting the FBI with understanding the scientific aspects of the anthrax attacks. Hank Heine, a fellow microbiologist, recounted that for approximately two and a half years, the department felt integral to the team's efforts to resolve the case.

Challenges in using genetic analysis to trace ...

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Collaboration between USAMRIID and the FBI in the Amerithrax investigation

Additional Materials

Counterarguments

  • The collaboration between the FBI and USAMRIID, while crucial, may have also led to potential conflicts of interest, especially considering that Bruce Ivins, a USAMRIID scientist, later became a suspect.
  • The reliance on USAMRIID's expertise raises questions about the independence of the investigation, as the source of the anthrax was ultimately traced back to a flask within USAMRIID itself.
  • The text does not address the potential for bias or error in the genetic analysis conducted by the scientists, which is a common challenge in forensic investigations.
  • The commitment of USAMRIID scientists is noted, but the text does not discuss the oversight or verification of their work by independent parties, which is a standard practice in scientific inquiry to ensure objectivity.
  • While the scientists from USAMRIID felt integral to the investigation, the text does not mention the contributions of other agencies or experts outside of USAMRIID, which could imply an incomplete picture of the collaborative effort.
  • The difficulty in d ...

Actionables

  • You can foster a deeper understanding of bioterrorism by reading up on historical cases and current safety protocols. By doing this, you'll gain a broader perspective on the complexities of bioterrorism response and prevention. For example, you might start with the history of the 2001 anthrax attacks and then explore how safety measures have evolved since then.
  • Engage in citizen science projects that contribute to public health research. Platforms like Zooniverse offer opportunities to assist in real scientific research, which can include categorizing data or identifying patterns that might be relevant to disease tracking. This participation can give you a sense of contributing to larger efforts similar to how scientists assist in investigations.
  • Develop critical thinking skills by parti ...

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The Anthrax Threat I 5. Mr. Anthrax

The forensic breakthrough with anthrax "morphs"

An accidental discovery in a USAMRIID lab has enabled a significant forensic breakthrough by using anthrax "morphs" to potentially trace the source of anthrax samples.

An accidental discovery of anthrax morphs led to a key forensic tool

When a USAMRIID technician named Terry inadvertently left anthrax samples in the incubator for a longer time than usual, the spores developed distinctive appearances. Rather than the typical small, puffy white clouds, these spores spread out, had defined edges, and took on a yellowish tint. This overgrowth led to the identification of "morphs," defined as morphological variants. These are rare mutations that occur when bacteria reproduce, often resulting in highly informative distinguishing characteristics between different types of anthrax.

Morphs could visually distinguish between anthrax samples

The significance of these morphs lies in their unique and identifiable features, which offer a new method to distinguish anthrax samples from each other. USAMRIID scientists were previously stymied by the fact that anthrax usually replicates in the same way each time, rendering DNA analyses of samples from different labs almost identical. The discovery of morphs, therefore, provided a vital forensic tool, akin to "a hair or a fiber or a fingerprint," which could link a specific strain of anthrax back to its source laboratory.

Extensive sampling of anthrax from labs pointed to USAMRI ...

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The forensic breakthrough with anthrax "morphs"

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Counterarguments

  • The identification of morphs, while significant, may not be the only method to trace the source of anthrax samples; other forensic techniques could also be relevant.
  • The uniqueness of morphs as a distinguishing feature could be challenged if similar mutations were found to occur in different environments or conditions, potentially complicating the forensic analysis.
  • The assumption that morphs are rare might be contested if further research shows that such mutations occur more frequently than initially thought.
  • The comparison of morphs to fingerprints might be overstated, as fingerprints are unique to individuals, whereas morphs might not be as uniquely tied to a single source.
  • The reliance on morphs for forensic tracing assumes a high level of containment and control over anthrax samples, which might not account for unauthorized or undocumented transfers.
  • The review conducted by the FBI, while extensive, might not have included all possible sources of the Ames strain, ...

Actionables

  • Explore the world of citizen science by participating in online projects that involve classifying images or data, which can be similar to identifying unique features in samples. Websites like Zooniverse offer a variety of projects where you can help researchers by analyzing images for specific characteristics, giving you a taste of how identifying unique features can contribute to scientific discovery.
  • Start a hobby in collecting and observing natural specimens, such as leaves, insects, or rocks, to develop an eye for distinguishing subtle differences. By creating a personal catalog of your findings, you can practice the skill of identifying unique traits, akin to how morphs distinguish anthrax samples. This can enhance your observational skills and attention to detail, which are valuable in various aspects of life.
  • Engage in puzzle games and apps that focus on pat ...

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The Anthrax Threat I 5. Mr. Anthrax

Suspicion and investigation of Bruce Ivins

Bruce Ivins, once known for his quirky and eccentric behavior, became a person of interest in an intense FBI investigation due to his questionable actions surrounding anthrax samples.

Ivins' unusual behavior raised red flags for investigators

Bruce Ivins was no stranger to unusual behavior, often engaging in light-hearted pranks and expressing his passions in creative ways, whether through juggling or charming colleagues with music and song. His intensity about hobbies and interests sometimes required colleagues to bluntly tell him to quiet down, and on one occasion, his superior had to autoclave his fungally-infected tennis shoes due to contamination concerns.

However, his quirky persona took a darker turn when he conducted unauthorized actions in the lab. Ivins carried out clean-up operations outside the scope of what was allowed, swabbing areas outside of the containment zones after a leak of anthrax. This action, particularly cleaning up stray spores in his own office without authorization, caught the attention of the FBI. Additionally, his unexpected presence at a pond dredging operation key to the Amerithrax investigation further raised suspicions about his involvement.

Ivins' role as custodian of the key anthrax sample drew scrutiny

As a preeminent scientist in pathogenic microbiology and developer of an anthrax vaccine, Ivins held a significant position within his field. This status came with the responsibility of being the sole custodian of the RMR-1029 flask, containing the very anthrax spores used in the attacks. His activities and history at the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) came under intense scrutiny.

The FBI harbored suspicions about Ivins over what seemed to be an attempt to clean his office and potentially destroy evidence. Ivins ...

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Suspicion and investigation of Bruce Ivins

Additional Materials

Clarifications

  • Autoclaving fungally-infected tennis shoes is a process of sterilizing shoes using high-pressure steam to kill any fungal spores or contaminants present on them. This method is commonly used in laboratory settings to ensure that items are free from harmful microorganisms before reuse. Autoclaving is a standard practice to maintain cleanliness and prevent the spread of pathogens in sensitive environments like research labs.
  • The RMR-1029 flask contained the specific strain of anthrax used in the 2001 attacks. Bruce Ivins, as the custodian of this flask, had direct access to the anthrax spores. The FBI focused on this flask as a key piece of evidence in their investigation into the anthrax attacks. Ivins' handling of this flask and his actions related to it raised suspicions about his potential involvement in the attacks.
  • The Amerithrax investigation was the FBI's probe into the 2001 anthrax attacks in the United States. It aimed to identify the source of the anthrax spores used in the attacks that followed the September 11 terrorist strikes. The investigation focused on determining who was responsible for mailing letters containing anthrax to various media outlets and government offices, resulting in multiple deaths and infections. The case involved extensive forensic analysis, scientific scrutiny, and a search for the perpetrator behind the bioterrorism incident.
  • The anthrax spores used in the attacks referenced in the text were part of a series of bioterrorism incidents that occurred in the United States in 2001. Letters containing anthrax spores were mailed to several media outlets and government offices, resulting in multiple deaths and infections. The spores were a highly refined form of the bacterium Bacillus anthracis, engineered to be more potent and easily dispersed. The attacks led to a signifi ...

Counterarguments

  • Quirky behavior is not indicative of guilt and can be common in highly intelligent or creative individuals.
  • Unauthorized lab actions could be a result of poor judgment or a misunderstanding of protocol rather than malicious intent.
  • Ivins' presence at the pond dredging operation could be coincidental or for reasons unrelated to the Amerithrax investigation.
  • Being the custodian of the anthrax sample does not automatically imply culpability in the attacks.
  • The suspicion of Ivins attempting to clean his office to destroy evidence could be unfounded without concrete proof of his intent to obstruct the investigation.
  • The faulty s ...

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The Anthrax Threat I 5. Mr. Anthrax

Tensions within the Amerithrax investigative team

Rick Lambert, lead investigator of the Amerithrax case, was unconvinced that Bruce Ivins was the culprit behind the anthrax attacks and faced pressures from FBI leadership to focus exclusively on him.

Lead investigator Rick Lambert was unconvinced Ivins was the culprit

During a March 2005 interview with Ivins, Rick Lambert noted his mild-mannered and cooperative nature, and when confronted about the anthrax mutations linked to his lab, Ivins responded in a way Lambert felt an innocent person would. Lambert's suspicions about Ivins were neither heightened nor dispelled following the interview, leaving him unconvinced of Ivins' guilt due to the lack of a definitive "smoking gun." Lambert informed FBI Director Mueller of his position, stating that the circumstantial evidence against Ivins did not amount to probable cause for charges.

Lambert wanted to investigate other potential sources, like Dugway and Battelle

Lambert pressed to extend the investigation beyond USAMRIID, but faced resistance. He harbored concerns about the possibility of broader access to the anthrax strain and the casual sharing of anthrax spores among researchers, indicating that other facilities, such as Dugway Proving Ground and the Battelle Institute, were equally compelling sources. Both Dugway and Battelle had access to anthrax with the same morphological variants as those found in the attack letters.

Lambert was especially critical of the incompleteness of anthrax submissions from these facilities and believed direct sampling by FBI agents with search warrants would have been more appropriate. Desp ...

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Tensions within the Amerithrax investigative team

Additional Materials

Counterarguments

  • The FBI leadership may have had additional undisclosed evidence or intelligence that pointed towards Ivins, which justified their focus on him.
  • Ivins' mild-mannered and cooperative nature during the interview does not preclude the possibility of his guilt; many individuals capable of serious crimes can present themselves as non-threatening.
  • The lack of a "smoking gun" does not necessarily mean Ivins was innocent, as circumstantial evidence can be compelling and sufficient for conviction in the absence of direct evidence.
  • The FBI's focus on Ivins could have been a strategic decision based on a risk assessment that prioritized the most likely suspect to ensure efficient use of resources.
  • The circumstantial evidence against Ivins might have met the threshold for probable cause in the context of the broader investigation, which Lambert may not have been fully privy to.
  • The scrutiny of other facilities like Dugway and Battelle, while important, may have already been conducted to the satisfaction of other members of the investigati ...

Actionables

  • Develop critical thinking by questioning the obvious in daily news stories. When you read or watch the news, practice identifying the "Ivins" in the story—the person or thing presented as the obvious cause or culprit. Then, consider alternative explanations or "suspects" that could also be responsible, much like Lambert wanted to investigate other sources. This exercise will sharpen your analytical skills and prevent you from accepting information at face value.
  • Enhance your decision-making by creating a "probable cause" checklist for personal use. Whenever you're faced with a decision that relies on circumstantial evidence, like choosing a service based on reviews, draft a list of criteria that must be met before you can conclude. This mirrors Lambert's approach to needing more than circumstantial evidence and ensures you make more informed decisions.
  • Practice resisting peer pressure by setting personal bou ...

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